PET and MRI in Prognosis Prediction of NPC

NCT03429868 | Completed DMC

• 1 other identifier: NSC 104-2314-B-182A-084-MY3
• Study Type: interventional
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

Nasopharyngeal carcinoma (NPC) differs from other head and neck malignancies terms of its epidemiology, pathology, and treatment outcome. Integrated PET/MRI is a new imaging modality, which can simultaneously acquire PET and MRI images. Considering the lack of reports on the use of hybrid PET/MRI systems in prognosis prediction in NPC, the investigators conduct this prospective study to investigate the roles of integrated PET/MRI parameters for predicting treatment outcome and prognosis in patients with NPC.

Conditions

Nasopharyngeal Carcinoma

Keywords

Nasopharyngeal carcinoma; Nead neck cancer; Prognosis; PET; MRI

Outcome Measures

Primary Outcomes (1)

• Overall survival

  Being calculated from the date of diagnosis to the date of death or censor at the date of the last follow- up for surviving patients.

  3 years

Secondary Outcomes (1)

• Recurrence-free survival

  3 years

Study Arms (1)

integrated PET/MRI

EXPERIMENTAL

The participants receive an integrated 18F-FDG PET/MRI during tumor staging.

Device: integrated PET/MRI

Interventions

integrated PET/MRI DEVICE

The participants receive an integrated 18F-FDG PET/MRI scan in addition to the conventional 18F-FDG PET/CT on the same day during tumor staging. Whole body 18F-FDG PET/CT is performed one hour after injection of 10mCi of 18F-FDG. 18F-FDG PET/MRI is done after the PET/CT scan. And no additional 18F-FDG is given to the patients in the PET/MRI scan.

integrated PET/MRI

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Biopsy proven primary nasopharyngeal carcinoma
• Age \> or = 20
• Willing to receive therapy
• The ability to provide written informed consent and receive the scheduled scans

You may not qualify if:

• Woman with pregnancy or during lactation
• A history of other malignancies or concomitant cancers in different anatomical locations
• Not suitable to receive the PET scan such as serum glucose levels of \> 200 mg/dL or space phobia

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

Study Sites (1)

Linkou Chang Gung Memorial Hospital

Taoyuan District, Taiwan

Location

Related Publications (1)

• Chan SC, Ng SH, Yeh CH, Lin YC, Lin CY, Wang JH, Cheng NM, Chen SH, Chang KP, Hsieh JC. Prognostic utility of 18F-FDG PET/MRI with intravoxel incoherent motion imaging in nasopharyngeal carcinoma. Eur J Nucl Med Mol Imaging. 2025 Dec;53(1):338-349. doi: 10.1007/s00259-025-07425-6. Epub 2025 Jul 2.

  PMID: 40601020 DERIVED

MeSH Terms

Conditions

Nasopharyngeal Carcinoma

Condition Hierarchy (Ancestors)

Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Nasopharyngeal Neoplasms; Pharyngeal Neoplasms; Otorhinolaryngologic Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Nasopharyngeal Diseases; Pharyngeal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases

Study Officials

• Sheng-Chieh Chan

  Chang Gung Memorial Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 6, 2018
• First Posted: February 12, 2018
• Study Start: August 1, 2015
• Primary Completion: July 31, 2020
• Study Completion: July 31, 2020
• Last Updated: May 10, 2023

Record last verified: 2020-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)