High-flow Nasal Oxygen in Palliative Care: Pilot Study

NCT03423888 | Completed

• 2 other identifiers: RC31/17/03512017-A03377-46
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

In palliative care, the relief of the dyspnea is necessary. Medications for the reduction of dyspnea have side effects. High-flow nasal cannula oxygen therapy (HFNC) is a new way to deliver oxygen. Investigators hypothesize that HNFC is an acceptable technic for the patient with dyspnea in palliative care. A pilot study with 30 patients will be conducted. Acceptability of HNFC will be studied by the time of use by patients of the HNFC during one week. The effectiveness of HNFC in relieving dyspnea will be studied using Borg scale.

Conditions

Dyspnea

Keywords

Dyspnea; palliative care; high-flow nasal oxygen; pilot study

Outcome Measures

Primary Outcomes (1)

• Acceptability of HNFC in patients with dyspnea in palliative care during one week

  Duration of use of HNFC: nurses will set up the device to the patient who can withdraw it at any time. It will then be noted the stop time and recovery of the device for a week, which will know the time of use and acceptability. If the patient wishes to permanently stop the use of the device, the stop time will be raised.

  7 days

Secondary Outcomes (3)

• Efficiency of high-flow nasal oxygen in palliative care with dyspnea

  At short term: one hour after the initiation and at long term: 24h and seven days after the start

• Efficiency of high-flow nasal oxygen in palliative care with Sp02

  At short term: one hour after the initiation and at long term: 24h and seven days after the start

• Efficiency of high-flow nasal oxygen in palliative care with respiratory rate

  At short term: one hour after the initiation and at long term: 24h and seven days after the start

Other Outcomes (1)

• Tolerance of high-flow nasal oxygen in palliative care

  At short term: one hour after the initiation and at long term: 24h and seven days after the start

Study Arms (1)

High-flow nasal oxygen

EXPERIMENTAL

Device: high-flow nasal cannula oxygen therapy (HNFC)

Interventions

high-flow nasal cannula oxygen therapy (HNFC) DEVICE

Set up of high-flow nasal oxygen for patient with dyspnea for a respiratory disease without possibility of curative care. Patients who require a treatment by oxygen are included. After 7 days of treatment, acceptability is evaluated by the duration of use of HNFC.

High-flow nasal oxygen

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient followed for respiratory failure with palliative care and :
• More than 18 years old
• Dyspnea related to a respiratory disease
• Hypoxemia requiring the introduction of more than 4 liters of oxygen for a sp02 \> 90%
• Patient affiliated to a social security system

You may not qualify if:

• Patient less than 18 years old
• Patient with guardianship, trusteeship
• No consent for participation at the study
• Project of curative care

Sponsors & Collaborators

• University Hospital, Toulouse: lead

Study Sites (1)

Hospital LARREY, CHU Toulouse

Toulouse, 31059, France

Location

MeSH Terms

Conditions

Dyspnea

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Marion DUPUIS, MD

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 26, 2018
• First Posted: February 6, 2018
• Study Start: February 13, 2018
• Primary Completion: January 25, 2022
• Study Completion: January 25, 2022
• Last Updated: April 14, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)