NCT03420378

Brief Summary

The purpose of this study is to investigate the presence of central sensitization in vitamin D deficiency and its effect on cutaneous silent period, pain, and quality of life. The secondary purpose of the study is to investigate whether a change in cutaneous silent period parameters, pain severity and neuropathic sensitization and quality of life after vitamin D replacement.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
51

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 28, 2018

Completed
Same day until next milestone

Study Start

First participant enrolled

January 28, 2018

Completed
8 days until next milestone

First Posted

Study publicly available on registry

February 5, 2018

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 19, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 19, 2018

Completed
Last Updated

December 20, 2018

Status Verified

December 1, 2018

Enrollment Period

11 months

First QC Date

January 28, 2018

Last Update Submit

December 19, 2018

Conditions

Vitamin D DeficiencyCentral Sensitisation

Keywords

Central SensitisationCutaneous Silent PeriodVitamin D Deficiency

Outcome Measures

Primary Outcomes (2)

  • cutaneous silent period latency (ms)

    the brief interruption in voluntary contraction that follows strong electrical stimulation (painful) of a cutaneous nerve

    8 weeks

  • cutaneous silent period duration (ms)

    the brief interruption in voluntary contraction that follows strong electrical stimulation (painful) of a cutaneous nerve

    8 weeks

Secondary Outcomes (3)

  • Visual analog scale (VAS) of pain

    8 weeks

  • Leeds assessment of neuropathic symptoms and signs (LANSS)

    8 weeks

  • The Nottingham Health Profile (NHP)

    8 weeks

Study Arms (1)

Interventional Arm

EXPERIMENTAL

Patients with vitamin D deficiency will receive vitamin D replacement therapy. Before and after therapy, cutaneous silent period will be measured from each upper extremity and latencies will be recorded. Their LANSS scores and Notthingham Health Profile will be recorded before and after treatment.

Dietary Supplement: vitamin D

Interventions

vitamin DDIETARY_SUPPLEMENT

Vitamin D replacement

Interventional Arm

Eligibility Criteria

Age18 Years - 65 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Presence of widespread pain
  • Presence of vitamin D deficit

You may not qualify if:

  • Any contraindication of performing silent cutaneous period
  • Any contraindication for vitamin d use
  • Presence of conditions that affect cutaneous silent period like the presence of carpal tunnel syndrome and polyneuropathies
  • Defective peripheric autonomic nervous system findings
  • Not being able to write and read
  • Not being able to communicate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Ozge Kenis Coskun

Istanbul, Kadikoy, 34738, Turkey (Türkiye)

Location

Related Publications (14)

  • Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004 Mar;79(3):362-71. doi: 10.1093/ajcn/79.3.362.

    PMID: 14985208BACKGROUND

  • Hamilton B. Vitamin D and human skeletal muscle. Scand J Med Sci Sports. 2010 Apr;20(2):182-90. doi: 10.1111/j.1600-0838.2009.01016.x. Epub 2009 Oct 5.

    PMID: 19807897BACKGROUND

  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6.

    PMID: 21646368BACKGROUND

  • Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008 Apr;87(4):1080S-6S. doi: 10.1093/ajcn/87.4.1080S.

    PMID: 18400738BACKGROUND

  • Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006 May;10(4):287-333. doi: 10.1016/j.ejpain.2005.06.009. Epub 2005 Aug 10.

    PMID: 16095934BACKGROUND

  • Lotfi A, Abdel-Nasser AM, Hamdy A, Omran AA, El-Rehany MA. Hypovitaminosis D in female patients with chronic low back pain. Clin Rheumatol. 2007 Nov;26(11):1895-901. doi: 10.1007/s10067-007-0603-4. Epub 2007 Mar 22.

    PMID: 17377737BACKGROUND

  • Wicherts IS, van Schoor NM, Boeke AJ, Visser M, Deeg DJ, Smit J, Knol DL, Lips P. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab. 2007 Jun;92(6):2058-65. doi: 10.1210/jc.2006-1525. Epub 2007 Mar 6.

    PMID: 17341569BACKGROUND

  • Mascarenhas R, Mobarhan S. Hypovitaminosis D-induced pain. Nutr Rev. 2004 Sep;62(9):354-9. doi: 10.1111/j.1753-4887.2004.tb00061.x.

    PMID: 15497769BACKGROUND

  • Gloth FM 3rd, Lindsay JM, Zelesnick LB, Greenough WB 3rd. Can vitamin D deficiency produce an unusual pain syndrome? Arch Intern Med. 1991 Aug;151(8):1662-4.

    PMID: 1872673BACKGROUND

  • Haroon M, FitzGerald O. Vitamin D deficiency: subclinical and clinical consequences on musculoskeletal health. Curr Rheumatol Rep. 2012 Jun;14(3):286-93. doi: 10.1007/s11926-012-0244-8.

    PMID: 22328176BACKGROUND

  • Tague SE, Clarke GL, Winter MK, McCarson KE, Wright DE, Smith PG. Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation. J Neurosci. 2011 Sep 28;31(39):13728-38. doi: 10.1523/JNEUROSCI.3637-11.2011.

    PMID: 21957236BACKGROUND

  • von Kanel R, Muller-Hartmannsgruber V, Kokinogenis G, Egloff N. Vitamin D and central hypersensitivity in patients with chronic pain. Pain Med. 2014 Sep;15(9):1609-18. doi: 10.1111/pme.12454. Epub 2014 Apr 14.

    PMID: 24730754BACKGROUND

  • Kuru P, Akyuz G, Yagci I, Giray E. Hypovitaminosis D in widespread pain: its effect on pain perception, quality of life and nerve conduction studies. Rheumatol Int. 2015 Feb;35(2):315-22. doi: 10.1007/s00296-014-3099-7. Epub 2014 Aug 2.

    PMID: 25085713BACKGROUND

  • Akyuz G, Sanal-Toprak C, Yagci I, Giray E, Kuru-Bektasoglu P. The effect of vitamin D supplementation on pain, quality of life, and nerve conduction studies in women with chronic widespread pain. Int J Rehabil Res. 2017 Mar;40(1):76-83. doi: 10.1097/MRR.0000000000000211.

    PMID: 28030514BACKGROUND

MeSH Terms

Conditions

Vitamin D Deficiency

Interventions

Vitamin D

Condition Hierarchy (Ancestors)

AvitaminosisDeficiency DiseasesMalnutritionNutrition DisordersNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

SecosteroidsSteroidsFused-Ring CompoundsPolycyclic Compounds

Study Officials

  • Ozge Kenis Coskun, MD

    Marmara Universtiy

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SCREENING
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 28, 2018

First Posted

February 5, 2018

Study Start

January 28, 2018

Primary Completion

December 19, 2018

Study Completion

December 19, 2018

Last Updated

December 20, 2018

Record last verified: 2018-12

Data Sharing

IPD Sharing
Will not share

Locations

TU(1)