Modeling Treated Recovery From Aphasia
(C-STAR) Center for the Study of Aphasia Recovery Modeling Treated Recovery From Aphasia
2 other identifiers
interventional
127
1 country
2
Brief Summary
Stroke is the leading cause of adult disability in the United States, and aphasia is common following a stroke to the left hemisphere of the brain. Aphasia therapy can improve aphasia recover; however, very little is known about how different patients respond to different types of treatments. The purpose of this study is to understand how the following factors influence an individual's response to aphasia treatment: 1) biographical factors (e.g., age, education, gender), 2) post-stroke cognitive/linguistic abilities and learning potential, and 3) the location and extent of post-stroke brain damage. We are also interested in understanding the kinds of treatment materials that should be emphasized in speech/language treatment. Overall, the goal of the current research is to inform the clinical management of post-stroke aphasia by identifying factors that can predict how an individual will respond to different treatment methods.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2016
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 2, 2016
CompletedFirst Submitted
Initial submission to the registry
January 23, 2018
CompletedFirst Posted
Study publicly available on registry
January 31, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
May 30, 2021
CompletedApril 28, 2022
April 1, 2022
4.8 years
January 23, 2018
April 27, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Philadelphia Naming Test
Assesses the ability to name functional objects
6 months
Study Arms (2)
Semantically focused treatment
ACTIVE COMPARATORThis treatment will focus on improving word finding and comprehension of information.
Phonologically focused treatment
ACTIVE COMPARATORThis treatment will focus on training speech sound production, targeting overall production abilities.
Interventions
Tasks are as follows: 1. Semantic feature analysis (SFA): For each pictured stimulus the patient is prompted to name the picture, and then to produce related words that represent features similar to the target word. 2. Semantic barrier task: The goal is for one participant (e.g., patient) to describe each card so that the other participant (e.g., clinician) can guess the picture on the card. Participants are only allowed to describe the semantic features of the target and the clinician models the kinds of cues that are allowed. 3. Verb network strengthening treatment (VNeST): This treatment targets lexical retrieval of verbs and their thematic nouns. The objective of VNeST is for the patient to generate verb-noun associates with the purpose of strengthening the connections between the verb and its uses. These are tasks used in clinical aphasia rehabilitation.
Tasks are as follows: 1. Phonological (sound) components analysis task: Participants are to name a given picture and then to identify the sound features of the target words (e.g., first sound, last sound, and rhyme). 2. Phonological production task: This tasks asks participants to sort and identify the sounds that make up a word. Various stages include identifying first sounds, last sounds, etc. Participants also work on blending sounds together to form words. 3. The phonological judgment task: A computerized presentation of verbs and nouns where participants are required to judge whether pairs of words include similar phonological features. These are tasks used in clinical aphasia rehabilitation.
Eligibility Criteria
You may qualify if:
- Experienced a left hemisphere ischemic or hemorrhagic stroke At least 12 months post-stroke
- Primarily English speaker for the past 20 years
- Ability to provide informed written or verbal consent MRI-compatible (e.g., no metal implants, not claustrophobic)
You may not qualify if:
- History of a right hemisphere stroke (Bilateral stroke)
- Clinically reported history of dementia, alcohol abuse, psychiatric disorder, traumatic brain injury, or extensive visual acuity or visual-spatial problems
- Severely limited speech production and/or auditory comprehension that interferes with adequate participation in the therapy provided
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Medical University of South Carolina
Charleston, South Carolina, 29425, United States
University of South Carolina
Columbia, South Carolina, 29208, United States
Related Publications (1)
Busby N, Wilmskoetter J, Gleichgerrcht E, Rorden C, Roth R, Newman-Norlund R, Hillis AE, Keller SS, de Bezenac C, Kristinsson S, Fridriksson J, Bonilha L. Advanced Brain Age and Chronic Poststroke Aphasia Severity. Neurology. 2023 Mar 14;100(11):e1166-e1176. doi: 10.1212/WNL.0000000000201693. Epub 2022 Dec 16.
PMID: 36526425DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Julius Fridriksson, PhD, CCC-SLP
University of South Carolina
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Endowed Professor
Study Record Dates
First Submitted
January 23, 2018
First Posted
January 31, 2018
Study Start
August 2, 2016
Primary Completion
May 30, 2021
Study Completion
May 30, 2021
Last Updated
April 28, 2022
Record last verified: 2022-04