Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN

NCT03408379 | Active Not Recruiting

• 1 other identifier: MMI_2017_27
• Study Type: observational
• Target: 230
• Locations: 1 country
• Sites: 1

Brief Summary

Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.

Conditions

Intracranial Aneurysms; Ruptured Aneurysm

Keywords

intracranial aneurysms; ruptured aneurysm; platelet activity

Outcome Measures

Primary Outcomes (1)

• Proportion of patients with platelet activation

  comparison of this proportion between patients with ruptured versus non ruptured intracranial aneurysm

  in the 7 days before embolisation

Interventions

Collection of blood sample in aneurysm OTHER

In case of an endovascular treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the procedure, an intra aneurysmal blood sample (1mL) will be taken during the procedure and a blood sample (arterial) of 1 mL will be taken at the end of the procedure. * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit. In case of a surgery treatment : * A blood sample (venous or arterial) of 10 ml will be taken at the beginning of the surgery. * A Tissue sample will be taken during the surgery * Iterative blood samples (arterial) of 10 mL will be taken at each follow up visit.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients presenting a single or multiple intracranial aneurysm for which an intervention is planned (endovascular treatment or surgery)

You may qualify if:

• Patient aged 18 and over
• Patient presenting a single or multiple aneurysm
• Patient presenting an intracranial aneurysm for which an intervention is planned (endovascular treatment or surgery) : elective intervention for an unruptured aneurysm or emergency surgery for a broken aneurysm

You may not qualify if:

• Pregnant or breast feeding woman
• Patient benefiting from legal protection measures

Sponsors & Collaborators

• Fondation Ophtalmologique Adolphe de Rothschild: lead

Study Sites (1)

Fondation Ophtalmologique A. de Rothschild

Paris, France, 75019, France

Location

MeSH Terms

Conditions

Intracranial Aneurysm; Aneurysm, Ruptured

Interventions

Vasodilation

Condition Hierarchy (Ancestors)

Intracranial Arterial Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Aneurysm; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Hemodynamics; Cardiovascular Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 17, 2018
• First Posted: January 24, 2018
• Study Start: December 20, 2017
• Primary Completion (Estimated): June 23, 2032
• Study Completion (Estimated): June 23, 2033
• Last Updated: January 20, 2026

Record last verified: 2026-01

Locations

FR (1)