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Investigator left NIH
Sponsor study identifier
Secondary identifiers
observational
98
1 country
1
Study Start
January 30, 2018
Actual (reported)Primary Completion
August 27, 2019
Actual (reported)Study Completion
September 30, 2019
Actual (reported)Background: Researchers want to test if certain cells can be re-programmed into stem cells. Stem cells can keep reproducing for a long time. Cells made by stem cells can be turned into different types of cells. These include cancer-fighting cells, skin cells, etc. The stem cells generated in this study will be used to make specific tumor-fighting cells that can recognize different types of mutations in cancer cells. They may also help identify new tumor mutations that may not have been identified yet. Objectives: To test if a certain type of tumor-fighting cells can be re-programmed into stem cells. Eligibility: Participants in another Surgery Branch protocol who are at least 16 years old Design: Participants already gave samples of blood and/or tumor tissue in the other protocol. They do not need to come back to the clinic or give any other samples. Participants will give consent for their samples to be used in this study. Researchers will obtain cells from the samples. They will grow those cells in the lab. They will create stem cells from them. Researchers will do genetic tests on the samples. Most tests will not show important health results. But if they do, the participant will be invited to talk to a genetic counselor and get more detailed testing to confirm the results. Some of the samples and results will be stored indefinitely. They may be used in future research. No personal information will be stored with them. ...
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 30, 2019
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 20, 2018
Actual (reported)January 23, 2018
Actual (reported)January 30, 2018
Actual (reported)August 27, 2019
Actual (reported)September 30, 2019
Actual (reported)Production of cancer antigen-specific T-cells
Reprogram patient specimens into induced pluripotent stem cells (iPSC) and differentiate them into different types of somatic cells
Approximately 10 years
Availability of stored specimens and/or data
Availability of stored specimens and/or data to approved research laboratories and investigators
Approximately 10 years
Patients with a cancer diagnosis enrolled on protocol 03-C-0277
Patients with a cancer diagnosis enrolled on protocol 03-C-0277
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H. Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cell. 2013 Jan 3;12(1):114-26. doi: 10.1016/j.stem.2012.11.002.
Vizcardo R, Masuda K, Yamada D, Ikawa T, Shimizu K, Fujii S, Koseki H, Kawamoto H. Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells. Cell Stem Cell. 2013 Jan 3;12(1):31-6. doi: 10.1016/j.stem.2012.12.006.
Peripheral blood lymphocytes, tumor-infiltrating lymphocytes, tissue
Steven A Rosenberg, M.D.
National Cancer Institute (NCI)
98 participants (actual enrollment reported by the registry).
First Submitted
January 20, 2018
First Posted
January 23, 2018
Study Start
January 30, 2018
Actual (reported)Contact the study team to confirm eligibility.
Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell. 2013 Aug 1;13(2):219-29. doi: 10.1016/j.stem.2013.04.004. Epub 2013 May 16.
Primary Completion
August 27, 2019
Actual (reported)Study Completion
September 30, 2019
Actual (reported)Last Updated
November 10, 2021
Record last verified: 2021-11
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Source: ClinicalTrials.gov.
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