Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study

NCT03404427 | Completed

• 1 other identifier: HANDY-SLEEP
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive. During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force. The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects. Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control. Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night. Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.

Conditions

Sleep Deprivation; Healthy Volunteers; Skeletal Muscle

Outcome Measures

Primary Outcomes (1)

• Test duration

  Time, in minutes, measured between the beginning of the endurance test and the end of the test, defined by the volunteer's inability to maintain a force of at least 30% of the maximum strength for 5 seconds.

  1 hour.

Study Arms (2)

Normal sleep night

SHAM COMPARATOR

The first endurance test is the endurance motor control test after a normal sleep night.

Behavioral: Normal sleep night

Sleepless night

EXPERIMENTAL

The first endurance test is the endurance motor test after a sleepless night.

Behavioral: Sleepless night

Interventions

Normal sleep night BEHAVIORAL

Usual hours of sleep

Normal sleep night

Sleepless night BEHAVIORAL

Total sleep deprivation the first night

Sleepless night

Eligibility Criteria

• Age: 25 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• adult male volunteers;
• to 45 years old
• regularly sleeping more than 6 hours per night;
• no excessive consumers of coffee (\<3 espressos / day);
• absence of muscular or neurological pathology ;
• with a BMI\> 18 and \<25 kg / m²;
• Horne and Ostberg score\> 31 and \<69 ;

You may not qualify if:

• female sex
• history of neuromuscular disease ;
• implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...)
• history of epilepsy, or discomfort after sleep deprivation ;
• poor sleepers (PSQI\> 5);
• exercising an activity in staggered hours;
• regularly performing more than 2 nights without sleep per month;
• taking drugs interfering with sleep (antidepressants, benzodiazepines ...);
• having crossed 4 time zones in the previous 4 weeks.
• current participation in another clinical research study;

Sponsors & Collaborators

• Poitiers University Hospital: lead

Study Sites (1)

Centre Hospitalier de Poitiers

Poitiers, Vienne, 86021, France

Location

Related Publications (1)

• Rault CCS, Heraud Q, Ansquer S, Ragot S, Kostencovska A, Thille AW, Stancu A, Saulnier PJ, Drouot X. Sleep Deprivation in Healthy Males Increases Muscle Afferents, Impairing Motor Preparation and Reducing Endurance. J Clin Neurophysiol. 2024 Nov 27;42(5):457-465. doi: 10.1097/WNP.0000000000001134.

  PMID: 39593197 DERIVED

MeSH Terms

Conditions

Sleep Deprivation

Condition Hierarchy (Ancestors)

Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Officials

• Xavier Drouot

  Poitiers University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: When analyzing the results (endurance, magnitude of the premotor potential), the outcomes assessor will not know if it is a normal night or a sleepless night
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: To compare the motor endurance of healthy subjects after a normal sleep night and after a sleepless night.

Study Record Dates

• First Submitted: January 12, 2018
• First Posted: January 19, 2018
• Study Start: February 14, 2019
• Primary Completion: March 4, 2020
• Study Completion: March 4, 2020
• Last Updated: April 21, 2020

Record last verified: 2020-04

Locations

FR (1)