Effects of Exercises Combined With Blood Flow Restriction in Healthy Individuals

NCT03401567 | Completed DMC

• 1 other identifier: 3408-GOA
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Purpose of the study is; to investigate the effect of exercises combined with blood flow restriction on strength, proprioception and functional motor performance in healthy individuals. There is no randomized controlled study of the effect of upper extremity exercises performed by restricting blood flow on the joint sensation of individuals and functional motor performance in healthy individuals. For this reason, purpose of the study is; to investigate the effect of exercises combined with blood flow restriction on strength, proprioception and functional motor performance in healthy individuals. Pain intensity with the numerical pain rating scale (NRS), muscle strength with digital hand dynamometer, shoulder and elbow proprioception with inclinometer, functional motor performance with Upper Extremity Closed Kinetic Chain Stabilization Test, Functional Throwing Performance Index, Single Arm Shot Put Test, Modified Pull-Up Test evaluation of 60 healthy individuals without neck and upper extremity pain, the fracture and surgical history for the upper extremity, cervical and thoracic area that prevent them to participate in the study will be made. Participants will randomly be separated into 2 groups of 30 people each. Elbow bending exercises with blood flow restriction will be performed to the exercise group during 6 weeks for 3 times a week accompanied by a physiotherapist. Control group will continue daily activities and a brochure on strengthening exercises and protection from injuries. Evaluations will be repeated 2 times and analyzed before the treatment and at the end of the 6th week. With the project, the investigators aim to improve the strength, improve proprioception and functional motor performance in healthy individuals by performing exercises restricting blood flow. With the achievement of the targets, exercises combined with blood flow restriction can be considered among the treatments protective for injuries, healing proprioception. The investigators also believe that the project will blaze the trail for the studies to be performed on athletes.

Conditions

Healthy Individuals

Keywords

blood flow restriction; proprioception; functional performance; muscle strength

Outcome Measures

Primary Outcomes (1)

• Strength

  Change of biceps and triceps muscles strength(in kg, with hand held dynamometer)

  Baseline and 6 weeks later

Secondary Outcomes (6)

• Shoulder proprioception

  Baseline and 6 weeks later

• Elbow proprioception

  Baseline and 6 weeks later

• Functional motor performance

  Baseline and 6 weeks later

• Functional motor performance

  Baseline and 6 weeks later

• Functional motor performance

  Baseline and 6 weeks later

Study Arms (2)

Exercise group

EXPERIMENTAL

Elbow bending exercises with blood flow restriction will be performed to the exercise group.

Other: Exercise group

Control group

NO INTERVENTION

Control group will continue daily activities and a brochure on strengthening exercises and protection from injuries.

Interventions

Exercise group OTHER

Elbow bending exercises with blood flow restriction will be performed to the exercise group during 6 weeks for 3 times a week. The first set of exercises will be 30 repetitions then 3 sets of 15 repetitions. Totally 75 repetitions will be performed. 30 seconds rest interval between sets will be given.

Exercise group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Being between the ages of 18-40
• Do not smoke
• Having full range of motion in neck, shoulder, and elbow
• Body mass index (BMI)˂30 kg/m2
• Able to complete the entire study procedure

You may not qualify if:

• Having fracture and surgical history for the upper extremity, cervical or thoracic area
• Having any systemic musculoskeletal disease
• Having neck and upper extremity pain
• Having a diagnosis of scoliosis and chest deformity
• Regularly playing sports with overhead activities (tennis, volleyball, handball, etc.)
• Have been exercising regularly for the last 6 months
• A history of anemia
• A history of cerebrovascular disease or myocardial infarction

Sponsors & Collaborators

• Dokuz Eylul University: lead

Study Sites (1)

Dokuz Eylul University

Izmir, Turkey (Türkiye)

Location

Related Publications (1)

• Yesilyaprak SS, Dere D. Elbow flexion training with blood flow restriction improves strength, proprioception, and performance in healthy individuals: a randomized controlled trial. BMC Musculoskelet Disord. 2025 Oct 16;26(1):976. doi: 10.1186/s12891-025-08768-9.

  PMID: 41102692 DERIVED

Study Officials

• Sevgi Sevi YESILYAPRAK, PhD

  Dokuz Eylul University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: All of the participants must have no neck and upper extremity pain, any fracture and surgical history for the upper extremity, cervical and thoracic area.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Postgraduate Student

Model Details: There are 2 groups of 30 people each. Elbow bending exercises with blood flow restriction will be performed to the exercise group during 6 weeks for 3 times a week. Control group will continue daily activities and a brochure on strengthening exercises and protection from injuries.

Study Record Dates

• First Submitted: December 23, 2017
• First Posted: January 17, 2018
• Study Start: April 18, 2018
• Primary Completion: December 20, 2018
• Study Completion: November 19, 2019
• Last Updated: November 21, 2019

Record last verified: 2017-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)