Cognitive Flexibility Training in Persistent Pain

NCT03398408 | Completed

• 1 other identifier: 201706064
• Study Type: interventional
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

To determine whether participation in a cognitive training program over a training period of five weeks improves cognitive flexibility in patients with chronic hip, knee, and back pain.

Conditions

Chronic Pain

Outcome Measures

Primary Outcomes (1)

• Does cognitive training over five weeks improve cognitive flexibility performance scores in chronic hip, knee, and back pain patients?

  The primary outcome, i.e. NCPT score, will be assessed before and after five weeks of cognitive training. T-test will be used to compare the change in NCPT score between the training and the control group.

  Up to 5 months

Study Arms (2)

Intervention

EXPERIMENTAL

Patients in both groups will complete paper-pencil TMT A and B and the CWMST, the computer-based TMT A and B and Color Match, and NCPT tests upon enrollment into the study. Participants in the intervention group will then be provided with the Lumosity cognitive flexibility training module and complete daily training for a total of five weeks. 1-3 days after completion of their training, all patients will be invited to complete the computerized versions of the TMT A and B, Color Match, and NCPT tests again on their personal computers.

Behavioral: Training

Control

NO INTERVENTION

Patients in both groups will complete paper-pencil TMT A and B and the CWMST, the computer-based TMT A and B and Color Match, and NCPT tests upon enrollment into the study. Patients in the control group will complete all tests upon enrollment and approximately five weeks after their initial testing, but will not participate in training.

Interventions

Training BEHAVIORAL

The intervention group will be provided with the cognitive training module and participants will be required to complete a targeted 36-minute daily training for 35 days.

Intervention

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults age 18 to 70 with chronic hip, knee, or low back pain for \>3 months
• Documented moderate to severe chronic pain
• English as a primary language
• Access to a computer at home and an email account

You may not qualify if:

• Diagnosed Alzheimer's or documented severe cognitive impairment
• Lack of email/lack of basic computer skills
• Has undergone an interventional pain procedure within one week prior to enrollment
• Are scheduled to undergo a pain procedure during the five weeks of complete cognitive training

Sponsors & Collaborators

• Washington University School of Medicine: lead
• Lumos Labs, Inc.: collaborator

Study Sites (1)

Washington University in St. Louis

St Louis, Missouri, 63110, United States

Location

Related Publications (18)

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  PMID: 20493746 BACKGROUND

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  PMID: 27101426 BACKGROUND

• Vachon-Presseau E, Tetreault P, Petre B, Huang L, Berger SE, Torbey S, Baria AT, Mansour AR, Hashmi JA, Griffith JW, Comasco E, Schnitzer TJ, Baliki MN, Apkarian AV. Corticolimbic anatomical characteristics predetermine risk for chronic pain. Brain. 2016 Jul;139(Pt 7):1958-70. doi: 10.1093/brain/aww100. Epub 2016 May 5.

  PMID: 27190016 BACKGROUND

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  PMID: 15010086 BACKGROUND

Related Links

• IASP Task Force for the Classification of Chronic Pain in ICD-11 Prepares New Criteria on Postsurgical and Posttraumatic Pain

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Simon Haroutounian, PhD

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Anesthesiology

Study Record Dates

• First Submitted: December 28, 2017
• First Posted: January 12, 2018
• Study Start: December 29, 2017
• Primary Completion: August 7, 2019
• Study Completion: August 7, 2019
• Last Updated: May 6, 2020

Record last verified: 2020-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)