Progression of Disease in Patients Newly Diagnosed With Glaucoma and Glaucoma Suspects Participating in the GATE Study

NCT03394521 | Completed

• 1 other identifier: 02/019/15
• Study Type: observational
• Target: 326
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to measure how many patients develop worsening glaucoma in the early years (2-4 years) of routine monitoring in hospital eye services. We will study a group of patients who were initially diagnosed as having glaucoma, or having high pressure in the eye (ocular hypertension) or having been diagnosed as a glaucoma suspect.

Conditions

Glaucoma

Keywords

glaucoma suspect; ocular hypertension; progression

Outcome Measures

Primary Outcomes (1)

• Development of glaucoma

  Proportion of glaucoma suspects and OHT patients who develop glaucoma annually up to 4 years after diagnosis in secondary care

  4 years

Secondary Outcomes (2)

• Progression of glaucoma

  1,2,3,4 years

• Predictors of disease progression

  4 years

Interventions

Routine clinical practice OTHER

This is an observational study

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Cohort of patients identified through the GATE study - newly referred from community to hospital eye services with suspected glaucoma

You may qualify if:

• \- Adults referred from community optometrists or general practitioner to hospital eye services with suspected glaucoma, including those with ocular hypertension.

You may not qualify if:

• Patients referred to hospital eye services because of other ocular disease;
• patients \< 18 years old;
• patients who cannot give informed consent,
• patients already diagnosed with glaucoma.
• This study cohort is further defined from the GATE population as
• Selection criteria:
• GATE study patients with a baseline diagnosis of OHT, Glaucoma suspect or Glaucoma (any mechanism);
• remaining in secondary care monitoring after first visit;
• recruited at Aberdeen Royal Infirmary or Hinchingbrooke Hospital NHS Trust.

Sponsors & Collaborators

• University of Aberdeen: lead
• Queen's University, Belfast: collaborator

MeSH Terms

Conditions

Glaucoma; Ocular Hypertension; Disease Progression

Condition Hierarchy (Ancestors)

Eye Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Katie Banister

  University of Aberdeen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 22, 2017
• First Posted: January 9, 2018
• Study Start: October 1, 2015
• Primary Completion: August 1, 2016
• Study Completion: August 1, 2016
• Last Updated: March 6, 2018

Record last verified: 2018-03