Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children

NCT03387969 | Unknown

• 1 other identifier: pediatric meningitis
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

Meningitis is one of the major lethal infectious diseases especially for the children in developing countries .It is not always possible and often very difficult to distinguish between bacterial and viral meningitis according to CSF findings, which is not accurate 100% and leads to unnecessary antibiotic usage , So We tried to find a useful 'bedside' decision-making tool, based on laboratory results readily available at the emergency department .

Conditions

Meningitis in Children

Outcome Measures

Primary Outcomes (1)

• differentiation between bacterial and viral meningitis

  by using simple bed side diagnostic test as CSF-CRP and procalcitonin confirmed by CSF culture sensitivity and CSF analysis with gram stain

  12 month

Study Arms (1)

meningitic group

Children suffering from fever , disturbed consciousnessand convulsion admitted in emergency department attending to assiut University Children Hospital aged between 2-18 years old

Procedure: CSF sample

Interventions

CSF sample PROCEDURE

for all patient CSF sample obtained for analysis , culture sensitvity and CSF-CRP. also blood samples will be collected and analyzed for serum procalcitonin

meningitic group

Eligibility Criteria

• Age: 2 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

children at pediatric emergency care unit attending to Assuit University Children Hospital Aged from 2 years to 18 years old presented with fever, convulsions, disturbed consciousness and possible meningeal sign

You may qualify if:

• Patients at pediatric emergency care unit characterized by:
• Age from 2 years to 18 years old.
• All patients with clinical features suggestive of meningitis presented with fever, convulsions and possible meningeal signs.
• Immuno-compermised patients or patients on steroids specially.

You may not qualify if:

• Patients above 18 years old .
• patient with acute infections at sites other than central nervous system.
• patients with severe hepatic dysfunction .
• patient with positive family history of metabolic disease .
• patients known to had congenital CNS abnormality.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (17)

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  BACKGROUND

• -Patel N, Patel U, Nagpal AC, Jain RK. Evaluating Utility of C reactive protein in Differentiating Bacterial from Non-Bacterial Meningitis in Tertiary Care Hospital, in Central India . International Journal of Medical Research and Review. April-June, 2013/ Vol 1/ Issue 2

  BACKGROUND

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Biospecimen

Retention: SAMPLES WITHOUT DNA

CSF analysis with culture sensitivity and gram stain . * CSF-CRP level measured by reagent nephelometric method by BN prospec seimense. * Serum procalcitonin level for all patient suspected with meningitis measured by chemilumensce on cobas E411 or by ELISA (enzyme linked immunoassay)

Central Study Contacts

amal abdelsalam soliman, MD

CONTACT

01067700334; amalsoliman47@gmail.com

safwat mohammed abd elaziz, MD

CONTACT

01003918080; safwatabdelaziz371@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: December 24, 2017
• First Posted: January 2, 2018
• Study Start: January 1, 2018
• Primary Completion: January 1, 2019
• Study Completion: July 1, 2020
• Last Updated: January 2, 2018

Record last verified: 2017-12