Trials Sponsors Conditions Drugs Pricing

Conditions

Diabetes Mellitus Heart Failure

Keywords

Heart Failure, Diabetes Mellitus, Mitochondrial Respiration

Outcome Measures

Primary Outcomes (1)

mitochondrial oxygen flux
measured using high resolution respirometry. Unit: pmol/(s\*mg)
Up to 36 months

Study Arms (3)

Control

Insulin Resistant

Type 2 Diabetes

Eligibility Criteria

Age20 Years - 85 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

patients undergoing myocardial biopsy, left ventricular assist device implantation or heart transplantation for medical reasons

You may qualify if:

age ≥ 20 and ≤85 years

Sponsors & Collaborators

German Diabetes Center
Otherlead
Heinrich-Heine University, Duesseldorf
Othercollaborator

Study Sites (1)

German Diabetes Center

Düsseldorf, North Rhine-Westphalia, 40223, Germany

Related Publications (2)

Zweck E, Scheiber D, Jelenik T, Bonner F, Horn P, Pesta D, Schultheiss HP, Boeken U, Akhyari P, Lichtenberg A, Kelm M, Roden M, Westenfeld R, Szendroedi J. Exposure to Type 2 Diabetes Provokes Mitochondrial Impairment in Apparently Healthy Human Hearts. Diabetes Care. 2021 May;44(5):e82-e84. doi: 10.2337/dc20-2255. No abstract available.
PMID: 33972315DERIVED
Jelenik T, Flogel U, Alvarez-Hernandez E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, Muller-Wieland D, Moellendorf S, Godecke A, Kelm M, Westenfeld R, Roden M, Szendroedi J. Insulin Resistance and Vulnerability to Cardiac Ischemia. Diabetes. 2018 Dec;67(12):2695-2702. doi: 10.2337/db18-0449. Epub 2018 Sep 26.
PMID: 30257974DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Myocardial biopsies blood samples

MeSH Terms

Conditions

Heart FailureDiabetes Mellitus

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular DiseasesGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

Julia Szendroedi, Prof., MD
German Diabetes Center
PRINCIPAL INVESTIGATOR

Enrollment

400 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

May 29, 2017

First Posted

December 29, 2017

Study Start

April 2016

Actual (reported)

Metabolic Determinants of Cardiac Function

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (3)

Control

Insulin Resistant

Type 2 Diabetes

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (2)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (3)

Control

Insulin Resistant

Type 2 Diabetes

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (2)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations