Salt Sensitivity Hypertension and Lens Opacities

NCT03385070 | Completed

• 1 other identifier: 8.3.2017/1325
• Study Type: observational
• Target: 429
• Locations: 1 country
• Sites: 1

Brief Summary

Salt-sensitive hypertension (SSH) accounts for about the half of all Hypertension (HT) cases .In SSH, Na+/K+-ATPase activity is impaired. Impaired Na+/K+-ATPase activity in the lens epithelium results in cortical opacities in the peripheral equator of the lens. This study analyzed 305 patients with hypertension aged between 40 and 80 years and 124 non-HT controls. A total of 163 patients with HT who were admitted to the emergency service at least once with a minimum increase of 10% in their systolic and diastolic blood pressure after consuming salted food met the eligible criteria for HT and were included in the SSH group. A total of 142 patients who were previously diagnosed with HT but had no previous history were considered non-SSH. Two researchers examined the presence of cortical lens opacities biomicroscopically using the diffuse, direct, Scheimpflug, and retroillumination from fundus methods.

Conditions

Salt Hypertension From Excess Dietary Salt; Lens Opacities

Outcome Measures

Primary Outcomes (1)

• Lens examination

  Biomicroscopic lens examination

  6 months

Study Arms (3)

Salt-sensitive group

Patients (n:163)with HT who presented at the emergency service at least once with a minimum increase in their systolic and diastolic blood pressure of 10% after consuming salty foods were included in the SSH group. Biomicroscopic lens examination,urine analysis for salt intake estimation,blood pressure measurements

Diagnostic Test: Lens examination

Salt resistance group

Patients(n:142) who did not exhibit this increase were included in the SRH group Biomicroscopic lens examination,urine analysis for salt intake estimation,blood pressure measurements

Diagnostic Test: Lens examination

Control group

Sex- and age-matched patients(n:124) without a HT diagnosis were included in the control group. Biomicroscopic lens examination,urine analysis for salt intake estimation,blood pressure measurements

Diagnostic Test: Lens examination

Interventions

Lens examination DIAGNOSTIC_TEST

The presence of cortical lens opacity was biomicroscopically examined by two researchers using the diffuse, direct, Scheimpflug and retroillumination from the fundus methods.

Also known as: urine analysis for salt intake, Blood pressure measurements

Control group; Salt resistance group; Salt-sensitive group

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The HT and control groups were subdivided into age groups of \< 50, 50-59, 60-69, and ≥ 70 years. These age groups comprised 54, 109, 80, and 62 patients in the HT group and 19, 42, 42, and 21 patients in the control group, respectively.

You may qualify if:

• Salt Sensitivity Hypertension patients Non-SSH, salt-resistant HT (SRH) patients Control patients without HT, aged 40-80 years.

You may not qualify if:

• Cataracts Diabetes Mellitus Smoking Hypo/hypercalcemia Hyperparathyroidism Eye trauma Coronary artery disease Cardiac failure Renal failure

Sponsors & Collaborators

• Kecioren Education and Training Hospital: lead

Study Sites (1)

University of Health Sciences.Keçiören Education and Training Hospital

Ankara, 06400, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Cataract

Interventions

Urinalysis; Blood Pressure

Condition Hierarchy (Ancestors)

Lens Diseases; Eye Diseases

Intervention Hierarchy (Ancestors)

Clinical Chemistry Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Urological; Investigative Techniques; Vital Signs; Physical Examination; Hemodynamics; Cardiovascular Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Şahbender Koç, Cardiologist

  Keçiören Education and Training Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 6 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Cardıologıst

Study Record Dates

• First Submitted: December 20, 2017
• First Posted: December 28, 2017
• Study Start: March 15, 2017
• Primary Completion: December 7, 2017
• Study Completion: December 7, 2017
• Last Updated: December 29, 2017

Record last verified: 2017-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)