MOVE for Your MIND

NCT03384602 | Completed

• 1 other identifier: 2017-01288
• Study Type: interventional
• Target: 195
• Locations: 1 country
• Sites: 1

Brief Summary

Among the most promising interventions targeting both cognitive and functional decline, is Exercise. However, evidence regarding exercise interventions among seniors with cognitive impairment are inconclusive, likely due to challenges of recruitment and adherence. Alternatively, seniors with subjective cognitive decline (SCD), who are not yet meeting objective criteria of cognitive impairment, but have been shown to have twice the conversion rate to dementia compared with healthy seniors, are more likely to be motivated to participate and adhere to exercise interventions. Thus, exercise interventions in seniors with SCD may provide a window of opportunity for early prevention of dementia and falls. The investigators aim to test the effect of a group exercise (multi-task Jaques-Dalcroze Eurhythmics) and a simple home strength exercise program on change of cognitive function and the rate of falling among seniors with SCD.

Conditions

Cognitive Decline; Fall

Keywords

subjective cognitive decline; falls prevention; cognitive function; dalcroze eurhythmics; home exercise program; seniors

Outcome Measures

Primary Outcomes (2)

• Change in cognitive function

  assessed with the CERAD-plus test

  12 months

• Rate of falls

  The circumstances and injuries associated with the fall will be ascertained with a questionnaire.

  12 months

Secondary Outcomes (27)

• Proportion of seniors with any falls and injurious falls

  12 months

• Rate of injurious falls

  12 months

• Cognitive function: verbal fluency test

  12 months

• Cognitive function: Boston Naming test

  12 months

• Cognitive function: Mini Mental State Exam

  12 months

Other Outcomes (10)

• Structural brain changes

  12 months

• Daily physical activity

  12 months

• Effect of life-time physical activity

  Baseline

Study Arms (3)

Dalcroze Eurhythmics program

ACTIVE COMPARATOR

music-based multi-task exercise intervention

Other: Dalcroze Eurhythmics Program

home exercise strength program

ACTIVE COMPARATOR

simple strength training program to perform individually at home

Other: home exercise strength program

Control group

NO INTERVENTION

no change in the daily activities, no exercise intervention

Interventions

Dalcroze Eurhythmics Program OTHER

music-based multi-task exercise in group setting

Dalcroze Eurhythmics program

home exercise strength program OTHER

simple strength exercise program to perform individually at home

home exercise strength program

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Age 70+, living in the community
• Meet the criterion for SCD defined by a score of ≥25 points on the MAC-Q questionnaire

You may not qualify if:

• Signs of mild cognitive impairment (MCI), MoCA score ≤24
• Score of ≥5 on the short form of the Geriatric Depression Scale (15items)
• Inability to walk or to come to the study entre
• Severe gait impairment or diseases with a risk of recurrent falling (e.g. Parkinson's disease/syndrome, Hemiplegia after stroke, symptomatic stenosis of the spinal canal, polyneuropathy, epilepsy, recurring vertigo, recurring syncope, heavy alcohol consumption)
• Currently engaged in regular (once a week or more) strength training instructed by a professional teacher and including the explicit aim to improve muscle strength, or regular (once a week or more) Dalcroze eurhythmics classes
• Active cancer or current cancer treatment
• Inability to read and/or speak German necessary to understand the instructions

Sponsors & Collaborators

• University of Zurich: lead
• Swiss National Science Foundation, Switzerland: collaborator
• University Hospital, Toulouse, France: collaborator
• Waid City Hospital, Zurich, Switzerland: collaborator
• Felix Platter Hospital, Basel, Switzerland: collaborator
• JungDiagnostics, Hamburg, Germany: collaborator
• Ferrari Data Solution: collaborator
• Vontobel Foundation, Switzerland: collaborator
• Age Stiftung, Zurich, Switzerland: collaborator
• Gemeinnützige Stiftung EMPIRIS, Alzheimer Fund, Zurich Switzerland: collaborator
• Stiftung für Demenzforschung in Basel, Switzerland: collaborator

Study Sites (1)

Centre on Aging and Mobility, University of Zurich

Zurich, 8037, Switzerland

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Heike A Bischoff, Prof. Dr. med., DrPH

  University of Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Two intervention groups: Active I = Dalcroze Eurhythmic Program Active II: simple home exercise program Control group: no change in daily activities, no intervention

Study Record Dates

• First Submitted: October 16, 2017
• First Posted: December 27, 2017
• Study Start: December 14, 2017
• Primary Completion: November 2, 2021
• Study Completion: November 2, 2022
• Last Updated: August 9, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)