Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia

NCT03381456 | Completed

• 2 other identifiers: 2013_512014-A00244-43
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Cortical excitability depends on inhibitory mechanisms efficiency among which long latency intracortical inhibition (LICI) can be studied by paired pulses transcranial magnetic stimulation (TMS). Some recent evidences suggest that LICI may be one of the mechanisms by which the motor comment is adapted to the ongoing motor task with LICI strength being dependent on task complexity. In writer cramp and musician cramp, two forms of dystonia, the cortical excitability is not correctly modulated in some complex gestures. the hypothesis is that this task dependent perturbation of excitability in writer cramp could be due to a lack of LICI efficiency.

Conditions

Dystonia, Primary

Outcome Measures

Primary Outcomes (1)

• long-interval intracortical inhibition (LICI) level

  Amount of inhibition at interstimulus intervals of between 50 to 300ms

  Baseline

Study Arms (2)

Healthy subject

EXPERIMENTAL

LICI

Other: LICI

Dystonic subject

EXPERIMENTAL

LICI

Other: LICI

Interventions

LICI OTHER

Paired pulse TMS to measure LICI and late cortical disinhibition

Dystonic subject; Healthy subject

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient with hand dystonia : writers cramp
• Subject affiliated to social security regimen.
• For healthy volunteers :
• Healthy volunteer without neurological disorders based on sensorimotor examination.
• Subject affiliated to social security regimen.

You may not qualify if:

• Subject unable to receive informed consent (dementia).
• Contraindication to Transcranial Magnetic Stimulation(TMS) (epilepsia, intracranial metalic foreign object, hearing device, cochlear implant).
• Patient using a psychotrope treatment.
• Patient under guardianship or curatorship.
• Pregnant or nursing women.
• Patient with a cardiac stimulator.
• For healthy volunteers only :
• Abnormal neurological evaluation based on sensorimotor examination or neurological history ( epilepsy, stroke ; brain or spinal cord surgery ; history of neurological disease affective sensitive and motor control)

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hôpital Roger Salengro, CHRU de Lille

Lille, France

Location

MeSH Terms

Conditions

Dystonic Disorders

Condition Hierarchy (Ancestors)

Movement Disorders; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Philippe Derambure, MD, PhD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: 10 patient with dystonia and 10 healthy subject paired by sex and age.

Study Record Dates

• First Submitted: December 18, 2017
• First Posted: December 22, 2017
• Study Start: April 1, 2015
• Primary Completion: April 1, 2017
• Study Completion: April 1, 2017
• Last Updated: December 22, 2017

Record last verified: 2017-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)