Agency in Dystonia

NCT03351218 | Completed

• 2 other identifiers: C17-042017-A01231-52
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia: (i) investigate various aspects of the sense of agency and relationship to the severity of dystonia symptoms, (ii) characterize the possible link between abnormalities of movement perception and alteration of sense of agency in dystonia, (iii) (identify the neuronal underpinnings of the defective sense of agency in dystonia.

Conditions

Dystonia, Primary

Outcome Measures

Primary Outcomes (2)

• agency tasks behavioral outcome measures

  response time

  throughout study completion, an average 2 years

• agency tasks behavioral outcome measures

  response accuracy in tasks trials

  throughout study completion, an average 2 years

Secondary Outcomes (2)

• MRI measures

  throughout study completion, an average 2 years

• MRI measures

  throughout study completion, an average 2 years

Study Arms (2)

Patients

OTHER

25 patients with cervical and 25 patients with myoclonus dystonia

Behavioral: Behavioral testing - computerized tasks

Controls

OTHER

50 healthy volunteers matched to patents ( age, sex)

Behavioral: Behavioral testing - computerized tasks

Interventions

Behavioral testing - computerized tasks BEHAVIORAL

Cognitive behavioral testing and cerebral MRI

Controls; Patients

Eligibility Criteria

• Age: 15 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis of isolated adult-onset cervical dystonia (CD) or myoclonus dystonia (MD);
• duration of disease of more than one year
• no botulinum toxin injection for at least three months before the study
• normal or corrected-to-normal vision.

You may not qualify if:

• any neurological history except for dystonia,
• history of dopamine antagonist treatment,
• secondary dystonia,
• dystonia in the upper limbs,
• inability to maintain gaze straight.

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France: lead

Study Sites (1)

Centre d'investigation Clinique

Paris, Île-de-France Region, 75013, France

Location

Related Publications (6)

• Tarrano C, Lamy JC, Delorme C, McGovern EM, Atkinson-Clement C, Brochard V, Thobois S, Tranchant C, Grabli D, Degos B, Corvol JC, Pedespan JM, Krystkoviak P, Houeto JL, Degardin A, Defebvre L, Apartis E, Vidailhet M, Roze E, Worbe Y. Tactile Temporal Discrimination Is Impaired in Myoclonus-Dystonia. Mov Disord. 2020 Dec;35(12):2356-2357. doi: 10.1002/mds.28253. Epub 2020 Sep 22. No abstract available.

  PMID: 32960985 RESULT

• Tarrano C, Wattiez N, Delorme C, McGovern EM, Brochard V, Thobois S, Tranchant C, Grabli D, Degos B, Corvol JC, Pedespan JM, Krystkoviak P, Houeto JL, Degardin A, Defebvre L, Valabregue R, Vidailhet M, Pouget P, Roze E, Worbe Y. Visual sensory processing is altered in myoclonus dystonia. Mov Disord. 2020 Jan;35(1):151-160. doi: 10.1002/mds.27857. Epub 2019 Sep 30.

  PMID: 31571302 RESULT

• Zito GA, Tarrano C, Jegatheesan P, Ekmen A, Beranger B, Rebsamen M, Hubsch C, Sangla S, Bonnet C, Delorme C, Meneret A, Degos B, Bouquet F, Brissard MA, Vidailhet M, Gallea C, Roze E, Worbe Y. Somatotopy of cervical dystonia in motor-cerebellar networks: Evidence from resting state fMRI. Parkinsonism Relat Disord. 2022 Jan;94:30-36. doi: 10.1016/j.parkreldis.2021.11.034. Epub 2021 Nov 30.

  PMID: 34875561 RESULT

• Zito GA, Tarrano C, Ouarab S, Jegatheesan P, Ekmen A, Beranger B, Valabregue R, Hubsch C, Sangla S, Bonnet C, Delorme C, Meneret A, Degos B, Bouquet F, Apoil Brissard M, Vidailhet M, Hasboun D, Worbe Y, Roze E, Gallea C. Fixel-Based Analysis Reveals Whole-Brain White Matter Abnormalities in Cervical Dystonia. Mov Disord. 2023 Jul;38(7):1187-1196. doi: 10.1002/mds.29425. Epub 2023 May 6.

  PMID: 37148555 RESULT

• Zito GA, Roze E, Tarrano C, Ouarab S, Jegatheesan P, Ekmen A, Beranger B, Valabregue R, Hubsch C, Sangla S, Bonnet C, Delorme C, Meneret A, Degos B, Bouquet F, Apoil Brissard M, Vidailhet M, Hasboun D, Pouget P, Worbe Y, Gallea C. Abnormal Connectivity of the Head Neural Integrator in Cervical Dystonia. Mov Disord. 2025 Nov;40(11):2321-2330. doi: 10.1002/mds.70014. Epub 2025 Sep 5.

  PMID: 40910449 RESULT

• Atkinson-Clement C, Tarrano C, Porte CA, Wattiez N, Delorme C, McGovern EM, Brochard V, Thobois S, Tranchant C, Grabli D, Degos B, Corvol JC, Pedespan JM, Krystkoviak P, Houeto JL, Degardin A, Defebvre L, Valabregue R, Rosso C, Apartis E, Vidailhet M, Pouget P, Roze E, Worbe Y. Dissociation in reactive and proactive inhibitory control in Myoclonus dystonia. Sci Rep. 2020 Aug 18;10(1):13933. doi: 10.1038/s41598-020-70926-x.

  PMID: 32811896 RESULT

MeSH Terms

Conditions

Dystonic Disorders

Condition Hierarchy (Ancestors)

Movement Disorders; Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Model Details: Two groups study : patients versus healthy controls

Study Record Dates

• First Submitted: October 10, 2017
• First Posted: November 22, 2017
• Study Start: October 23, 2017
• Primary Completion: October 15, 2020
• Study Completion: December 20, 2022
• Last Updated: December 4, 2025

Record last verified: 2025-03

Locations

FR (1)