Gut Microbiota, Short Chain Fatty Acids, and Adiposity Across The Epidemiological Transition

NCT03378765 | Active Not Recruiting

• 1 other identifier: 209537
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to define associations between gut microbiota, SCFAs and obesity in populations spanning the epidemiologic transition, and explore mechanisms by which these factors may independently and collectively influence the development of obesity. The central hypothesis of this study is that the composition of gut microbiota drives SCFA production which in turn influences obesity risk at the population-level.

Conditions

Obesity; Diabetes

Outcome Measures

Primary Outcomes (1)

• BMI

  Difference in body weight index (BMI) between high and low activity energy expenditure (AEE) groups.

  24 months

Study Arms (1)

African origin adults

African origin adults from Ghana, Jamaica, Seychelles, South Africa and USA between the ages of 30- 50.

Behavioral: Diet and physical activity monitoring

Interventions

Diet and physical activity monitoring BEHAVIORAL

Lifestyle monitoring

African origin adults

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study is comprises a complex samples population based approach drawn from communities in 5 countries: Ghana, Seychelles, South Africa, Jamaica and the US. Approximately 500 participants are enrolled per site for an unweighted total of 2500 participants.

You may qualify if:

• Identify as African American or Black
• Age 18-50

You may not qualify if:

• Pregnancy, nursing, or planning to become pregnant
• Movement disorders or other disability that limits mobility

Sponsors & Collaborators

• Loyola University: lead

Study Sites (1)

Loyola University Chicago

Maywood, Illinois, 60153, United States

Location

Related Publications (2)

• Luke A, Bovet P, Forrester TE, Lambert EV, Plange-Rhule J, Schoeller DA, Dugas LR, Durazo-Arvizu RA, Shoham D, Cooper RS, Brage S, Ekelund U, Steyn NP. Protocol for the modeling the epidemiologic transition study: a longitudinal observational study of energy balance and change in body weight, diabetes and cardiovascular disease risk. BMC Public Health. 2011 Dec 14;11:927. doi: 10.1186/1471-2458-11-927.

  PMID: 22168992 BACKGROUND

• Dugas LR, Lie L, Plange-Rhule J, Bedu-Addo K, Bovet P, Lambert EV, Forrester TE, Luke A, Gilbert JA, Layden BT. Gut microbiota, short chain fatty acids, and obesity across the epidemiologic transition: the METS-Microbiome study protocol. BMC Public Health. 2018 Aug 6;18(1):978. doi: 10.1186/s12889-018-5879-6.

  PMID: 30081857 DERIVED

Related Links

• METS microbiome project website

MeSH Terms

Conditions

Obesity; Diabetes Mellitus

Interventions

Diet

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 14, 2017
• First Posted: December 20, 2017
• Study Start: January 2, 2018
• Primary Completion: March 1, 2025
• Study Completion: March 1, 2025
• Last Updated: March 19, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)