Reference Values and Clinical Screening Test of Diffuse Noxious Inhibitory Controls (DNIC)

NCT03376867 | Active Not Recruiting

• 1 other identifier: 2018-2422
• Study Type: observational
• Target: 468
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic pain (CP) is disabling for people triggering important costs for society. A deficit of diffuse noxious inhibitory controls (DNIC) is one of the CP mechanisms. DNICs are evaluated in research setting using a CPM protocol (conditioned pain modulation). There is a lack of reference values on the effectiveness of DNICs. Wider research on DNIC will help to understand CP and to develop a clinical screening test evaluating DNICs.

Conditions

Chronic Pain

Keywords

conditioned pain modulation (CPM); Diffuse Noxious Inhibitory Controls (DNIC); pressure pain threshold (PPT); reference values; clinical decision rule

Outcome Measures

Primary Outcomes (1)

• Conditioned pain modulation

  Alteration (reduction or augmentation) of pain sensitivity after activation of endogenous pain-inhibitory system, measured by computerized visual analog scale (CoVAS) ranging from 0 \[no pain\] to 100 \[most intense pain that could be tolerated\]

  Once, at baseline, at recruitment (comparison between 1st and 2nd test, after the conditioning stimuli)

Secondary Outcomes (1)

• pressure points threshold

  Twice, at baseline, at recruitment (before and after the conditioning stimuli)

Study Arms (2)

Healthy volunteers

Conditioned pain modulation (2 stimuli test: heat and pressure points) before and after conditioning stimuli (cold water bath).

Other: Conditioned pain modulation

Volunteers with chronic pain

Conditioned pain modulation (2 stimuli test: heat and pressure points) before and after conditioning stimuli (cold water bath).

Other: Conditioned pain modulation

Interventions

Conditioned pain modulation OTHER

Conditioned pain modulation (CPM) protocol consist of evaluating pain during two stimuli test (heat and pressure point), before and after one conditioning stimulus (cold water bath); Blood analyses for biochemistry and genes polymorphisms.

Also known as: Pressure points

Healthy volunteers; Volunteers with chronic pain

Eligibility Criteria

• Age: 18 Years - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy male and female volunteers (with no pain) will provide reference values to further study volunteers with chronic pain. People with chronic pain will constitute a second group to associate the conditioned pain modulation to their pain (chronic pain is defined by any regular pain for more than 6 months except pain caused by cancer or migraine)

You may qualify if:

• years old
• Able to provide consent

You may not qualify if:

• cardiovascular disease (arrhythmia, cerebrovascular accident, infarction...)
• Raynaud syndrome
• severe psychiatric disease (dementia, schizophrenia, psychosis, major depression)
• injuries or loss sensitivity to their forearms or hands
• pregnant women or in post-partum period (\<1 year)

Sponsors & Collaborators

• Université de Sherbrooke: lead
• Canadian Institutes of Health Research (CIHR): collaborator
• Centre for Research of CHUS (CRCHUS): collaborator
• CIHR/SPOR - chronic pain network: collaborator

Study Sites (1)

Universite de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada

Location

Related Publications (1)

• Vincenot M, Leonard G, Cloutier-Langevin C, Bordeleau M, Gendron L, Camirand Lemyre F, Marchand S. Exploring the Spectrum of Temporal Summation and Conditioned Pain Modulation Responses in Pain-Free Individuals Using a Tonic Heat Pain and Cold Pressor Test Paradigms. Eur J Pain. 2025 May;29(5):e70019. doi: 10.1002/ejp.70019.

  PMID: 40176749 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples will be preserved as plasma (for biochemical analysis) and as Buffy coat cells (for genetic analysis on specific genes)

MeSH Terms

Conditions

Chronic Pain

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Louis Gendron, PhD

  Université de Sherbrooke

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 7, 2017
• First Posted: December 19, 2017
• Study Start: November 27, 2017
• Primary Completion: February 28, 2022
• Study Completion: December 30, 2024
• Last Updated: February 15, 2024

Record last verified: 2024-02

Locations

CA (1)