Immunodeficiency for Severe Epstein-Barr Virus Infection

NCT03374566 | Completed DMC

• 1 other identifier: EBV
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the immune responses associated with Epstein-Barr virus infections, and to find out the possible immunodeficiency that may be linked to severe Epstein-Barr virus infections.

Conditions

Epstein-Barr Virus Infections; Immunodeficiency

Keywords

Epstein-Barr Virus Infections; Immunodeficiency; Screening; Immunologic Function

Outcome Measures

Primary Outcomes (1)

• Immunodeficiency incidence in patients with severe EBV infection

  We will investigate immunodeficiency incidence in patients with severe EBV infection.

  5 years

Study Arms (1)

Screened patients

Immunodeficiency screening: Heparinized peripheral blood is obtained from patients with severe EBV infections for immunological function assays and genetic analysis, when current screening is performed after parents' information and consent.

Eligibility Criteria

• Age: 1 Day - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

We will evaluate immunodeficiency incidence in patients with severe EBV infection

You may qualify if:

• \. Age：birth to 18 years 2. Severe Epstein-Barr Virus infection

You may not qualify if:

• \. Lack of parental consent

Sponsors & Collaborators

• Children's Hospital of Fudan University: lead

Study Sites (1)

Children's Hospital of Fudan University

Shanghai, Shanghai Municipality, China

Location

Related Publications (6)

• Worth AJ, Houldcroft CJ, Booth C. Severe Epstein-Barr virus infection in primary immunodeficiency and the normal host. Br J Haematol. 2016 Nov;175(4):559-576. doi: 10.1111/bjh.14339. Epub 2016 Oct 17.

  PMID: 27748521 BACKGROUND

• Shabani M, Nichols KE, Rezaei N. Primary immunodeficiencies associated with EBV-Induced lymphoproliferative disorders. Crit Rev Oncol Hematol. 2016 Dec;108:109-127. doi: 10.1016/j.critrevonc.2016.10.014. Epub 2016 Nov 2.

  PMID: 27931829 BACKGROUND

• Palendira U, Rickinson AB. Primary immunodeficiencies and the control of Epstein-Barr virus infection. Ann N Y Acad Sci. 2015 Nov;1356:22-44. doi: 10.1111/nyas.12937. Epub 2015 Sep 28.

  PMID: 26415106 BACKGROUND

• Taylor GS, Long HM, Brooks JM, Rickinson AB, Hislop AD. The immunology of Epstein-Barr virus-induced disease. Annu Rev Immunol. 2015;33:787-821. doi: 10.1146/annurev-immunol-032414-112326. Epub 2015 Feb 11.

  PMID: 25706097 BACKGROUND

• Fujiwara S, Kimura H, Imadome K, Arai A, Kodama E, Morio T, Shimizu N, Wakiguchi H. Current research on chronic active Epstein-Barr virus infection in Japan. Pediatr Int. 2014 Apr;56(2):159-66. doi: 10.1111/ped.12314.

  PMID: 24528553 BACKGROUND

• Eligio P, Delia R, Valeria G. EBV Chronic Infections. Mediterr J Hematol Infect Dis. 2010 Aug 10;2(1):e2010022. doi: 10.4084/MJHID.2010.022.

  PMID: 21415952 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Heparinized peripheral blood is obtained from patients with severe EBV infections. Samples is performed after parents' information and consent.

MeSH Terms

Conditions

Epstein-Barr Virus Infections; Immunologic Deficiency Syndromes

Condition Hierarchy (Ancestors)

Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Tumor Virus Infections; Immune System Diseases

Study Officials

• Jinqiao Sun, Ph.D.,M.D

  Children's Hospital of Fudan University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 12, 2017
• First Posted: December 15, 2017
• Study Start: December 1, 2017
• Primary Completion: October 30, 2022
• Study Completion: February 1, 2023
• Last Updated: February 9, 2023

Record last verified: 2023-02

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)