Attributional Style and Parkinson's Disease

NCT03371277 | Completed

• 1 other identifier: PO17112
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural instability, patients suffer with non-motor symptoms such as dysautonomia syndrome, sleep disturbances, depressive disorders, delusional disorders and cognitive disorders. Research and management of these non-motor symptoms is essential because these can be disabling and have a negative impact on the quality of life of patients. Among cognitive functions, social cognition is defined as the aspect that is dedicated to process social information for adaptive functioning. More specifically, it refers to an intricate set of higher-order neuropsychological domains that allow for adaptive behaviors in response to others. Four dimensions are usually included in this construct: theory of mind (ToM), emotion processing, social perception and social knowledge, and attributional style. Recently, different categories of social cognition have been studied in patients suffering from PD, such as the ToM or the recognition of facial emotions. Other aspects of social cognition that seem relevant in this population are still poorly studied; the attributional style is a cognitive bias defined as "the way we explain the causes of the positive or negative events that occur". Indeed, different causes can be attributed to an event, and this attribution is shared between oneself, others and other factors related to the situation. People with attribution bias may mistakenly attribute to one cause all the situations. For example, when an individual blame the others for an event, he may develop a feeling of hostility that may lead to maladaptive behavior such as aggression and thus affect his social functioning. The impact of PD treatments, particularly deep brain stimulation (DBS), on the ToM has been studied, showing a deficit after stimulation. No study has assessed the impact of therapeutics on the attributional style of PD patients. In this context, it seems relevant to evaluate the effect of deep brain stimulation on the attributional style in this population.

Conditions

Parkinson's Disease

Outcome Measures

Primary Outcomes (1)

• Attributional style

  The Ambiguous Intentions Hostility Questionnaire (Combs et al., 2006) will be used to assess attributional style

  Day 0

Secondary Outcomes (1)

• depression

  Day 0

Study Arms (2)

Arm1

EXPERIMENTAL

patients with Parkinson's disease treated with deep brain stimulation.

Other: Medical visit for specific questionnaires

Arm2

EXPERIMENTAL

patients with Parkinson's disease treated without deep brain stimulation.

Other: Medical visit for specific questionnaires

Interventions

Medical visit for specific questionnaires OTHER

Ambiguous Intentions Hostility Questionnaire (AIHQ) developed by Combs (2007)

Arm1; Arm2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnostic of Parkinson's disease by a neurologist
• Native French speaker
• Affiliated to social security
• Over 18 years-old
• Accepting the study after reading the information note and signing the consentment form

You may not qualify if:

• Diagnostic of bipolar disorder or schizophrenia
• Abuse and dependence on psychoactive substances according to the DSM V criteria
• Disabling sensory disorders
• Mental retardation or cognitive deterioration (e.g. dementia), with the incapacity to answer to the questionnaires.
• Patients under guardianship or curatorship

Sponsors & Collaborators

• CHU de Reims: lead

Study Sites (1)

Chu Reims

Reims, 51092, France

Location

Related Publications (1)

• Decombe L, Henry A, Decombe R, Tir M, Doe de Maindreville A, Galland Hairabedian L, Kaladjian A, Raucher-Chene D. "Accidental, really?" Attributional bias in patients with Parkinson's disease. Parkinsonism Relat Disord. 2022 Feb;95:18-22. doi: 10.1016/j.parkreldis.2021.12.013. Epub 2021 Dec 23.

  PMID: 34959046 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 7, 2017
• First Posted: December 13, 2017
• Study Start: January 22, 2018
• Primary Completion: July 7, 2018
• Study Completion: July 7, 2018
• Last Updated: January 21, 2026

Record last verified: 2018-10

Locations

FR (1)