NCT03370042

Brief Summary

Background and Objective: Gingival recession accounts for apical migration of the gingival margin resulting in exposure of the cementoenamel junction (CEJ) and root surface. It is a matter of concern for both patients and dental professionals, especially when exposure of the root surface is linked to deterioration in esthetic appearance and increase in dentinal hypersensitivity which leads to improvements in various surgical techniques that have been used to correct labial gingival recession defects. The present study thus was aimed to evaluate and compare the results of Semilunar Coronally Positioned Flap alone and Semilunar Coronally Positioned Flap in Conjunction with Free Gingival Graft for treatment of Miller Class I and II gingival recession defects in maxillary anterior teeth. Materials and Method: A total of 20 bilateral Miller's class I and II gingival recession sites in systemically healthy subjects, 20-45 years of age were recruited for this study. Recession sites were divided and randomly allocated to either of the two groups SCPF+FGG (test group) and SCPF (control group) with 10 sites per group to be treated with semilunar coronally positioned flap with free gingival graft technique for SCPF+FGG group and semilunar coronally positioned flap technique alone for SCPF group. Longitudinal alterations during a follow-up period of 1, 3, 6 and 12 months in terms of Probing depth (PD), Recession width (RW), Recession height (RH), Width of keratinized tissue (WKT) and Clinical attachment level (CAL) were measured for both the groups and the values were statistically analysed.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2015

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 14, 2015

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 7, 2016

Completed
25 days until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2016

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

December 2, 2017

Completed
10 days until next milestone

First Posted

Study publicly available on registry

December 12, 2017

Completed
2.2 years until next milestone

Results Posted

Study results publicly available

March 11, 2020

Completed
Last Updated

March 11, 2020

Status Verified

March 1, 2020

Enrollment Period

1.6 years

First QC Date

December 2, 2017

Results QC Date

April 11, 2018

Last Update Submit

March 7, 2020

Conditions

Keywords

aestheticsroot coveragesemilunar coronally positioned flapfree gingival graftwidth of keratinised tissue

Outcome Measures

Primary Outcomes (2)

  • Recession Height

    measured from cemento enamel junction to the most apical part of gingival margin

    12 months

  • Width of Keratinized Tissue

    measured from most apical part of gingival recession to the mucogingival junction

    12 months

Secondary Outcomes (3)

  • Clinical Attachment Level

    12 months

  • Probing Depth

    12 months

  • Recession Width

    12 months

Study Arms (2)

Semilunar Coronally Positiones Flap + Free Gingival Graft

ACTIVE COMPARATOR

semilunar coronally positioned flap with free gingival graft for root coverage

Procedure: semilunar coronally positioned flap with free gingival graft

Semilunar Coronally Positioned Flap

SHAM COMPARATOR

semilunar coronally positioned flap alone without free gingival graft for root coverage

Procedure: semilunar coronally positioned flap alone

Interventions

Also known as: combination technique
Semilunar Coronally Positiones Flap + Free Gingival Graft
Also known as: pedicle flap
Semilunar Coronally Positioned Flap

Eligibility Criteria

Age20 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Bilateral Miller Class I and II gingival recessions in maxillary anterior teeth

You may not qualify if:

  • systemic conditions known to interfere with periodontal healing
  • history of addiction or drinking alcohol
  • Systemic or local bone diseases
  • Pregnancy and lactating females
  • using anticoagulant or immune suppressor drugs
  • the patients who are unable to maintain oral hygiene
  • presence of Type II and V caries and
  • smokers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Gingival Recession

Condition Hierarchy (Ancestors)

Gingival DiseasesPeriodontal DiseasesMouth DiseasesStomatognathic DiseasesPeriodontal Atrophy

Limitations and Caveats

The stabilisation of the donor graft with sutures over the recipient bed as it requires exceedingly small section of donor tissue. FGG placed apical to the flap may undergo shrinkage affecting the root coverage on long term.

Results Point of Contact

Title
Dr. Raga Bindu
Organization
Kamineni Institute of dental sciences

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Post Graduate

Study Record Dates

First Submitted

December 2, 2017

First Posted

December 12, 2017

Study Start

February 14, 2015

Primary Completion

October 7, 2016

Study Completion

November 1, 2016

Last Updated

March 11, 2020

Results First Posted

March 11, 2020

Record last verified: 2020-03