Epidemiology of Post-influenza Bacterial Pneumonia Due to a Panton-Valentine Leukocidin Positive Staphylococcus Aureus

NCT03367624 | Unknown

• 1 other identifier: RNI2017/FLUVALENTINE-BAUX/YB
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Secondary bacterial influenza pneumonia caused by Panton-Valentine Leukocidin Positive Staphylococcus aureus is a rare complication but with poor prognosis. This pathology seems to affect young patients (20-40 years) without any medical history. Since the influenza pandemic of 2009, this complication is more and more mentioned, sought and diagnosed. However, the literature is poor, consisting of case reports, experimental studies on murine models, and low-power studies. The main objective is to evaluate the mortality in intensive care units of patients post-influenza bacterial pneumonia due to a Panton-Valentine Leukocidin positive Staphylococcus aureus

Conditions

Influenza; Staphylococcus Aureus Pneumonia; PV Leukocidin

Keywords

influenza; Staphylococcus Aureus; Pneumonia; PV leukocidin; ICU

Outcome Measures

Primary Outcomes (1)

• Number of dead patients

  All cause of mortality

  During Length of stay in intensive care unit (an average of 2 weeks)

Secondary Outcomes (39)

• Demographic data relating to age

  Baseline

• Demographic data relating to sex

  Baseline

• Respiratory failure

  Baseline

• Demographic data relating to immunosuppression

  Baseline

• risk factors for methicillin-resistant Staphylococcus aureus

  Baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalized in intensive care units for the management of influenza pneumonia infected with Panton-Valentine Leukocidin Positive Staphylococcus aureus over a retrospective period from 2009 to winter 2016-2017.

You may qualify if:

• Patient treated for post-influenza bacterial pneumonia due to a Panton-Valentine Leukocidin positive Staphylococcus aureus in intensive care unit

You may not qualify if:

• Minor patient
• Patient under protective measurement
• Absence of bacteriological and / or virological documentation

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

Baux

Nancy, 54000, France

RECRUITING

MeSH Terms

Conditions

Influenza, Human; Pneumonia, Staphylococcal; Staphylococcal Infections; Pneumonia

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Pneumonia, Bacterial; Lung Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 18, 2017
• First Posted: December 11, 2017
• Study Start: October 1, 2017
• Primary Completion: October 20, 2017
• Study Completion: March 1, 2018
• Last Updated: December 11, 2017

Record last verified: 2017-11

Locations

FR (1)