NCT03361332|UnknownDMC
The Sense of Agency
SOA
Behavioural and Neurofunctional Correlates of the Sense of Agency
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SOA
Behavioural and Neurofunctional Correlates of the Sense of Agency
Sponsor study identifier
observational
50
1 country
1
Study Start
April 8, 2017
Actual (reported)Primary Completion
July 29, 2017
Actual (reported)Study Completion
January 23, 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The ability to recognize of being the actors of the behaviour and its consequences, the so-called "Sense of Agency" (SoA), is a crucial component of self-awareness. One key aspect is the distinction from a mere inference about the causality between an act and its consequences and the sense of being the agent of it. Despite a large number of behavioural studies, there is unsatisfactory evidence on the functional anatomical underpinnings of the SoA and the distinction between causality and the SoA proper. Here, the investigators use an implicit measurement of the SoA and its modulations during fMRI: the intentional binding phenomenon (IB). The ivestigators also study how the SoA and the ensuing neurophysiological correlates are modulated by the presence of a movement disorders, such as Gilles de la Tourette Syndrome.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 23, 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 8, 2017
Actual (reported)July 29, 2017
Actual (reported)November 28, 2017
Actual (reported)December 4, 2017
Actual (reported)January 23, 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
BOLD signal changes
The investigators will measure the changes of the BOLD signal associated with the modification of the sense of agency both in healthy subjects and neurological patients.
April 2017 - October 2019
Subjects and patients will perform temporal-judgment-tasks (considered an indirect measure of the sense of agency) in an event-related fMRI setting. In the first task, they will hear a sound either caused by a voluntary key press or by the passive displacement of the same finger by the experimenter. Following each trial, subjects will estimate the delay between the finger movement and the subsequent sound, which will be presented at variable latencies after the key press. There will be also control-trials characterized by the active or passive movement with a subsequent sound presented with a delay that excludes causality inferences.
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Healthy controls and patients with Gilles de la Tourette Syndrome
IRCCS Galeazzi Orthopedic Hospital
Milan, 20161, Italy
First Submitted
November 28, 2017
First Posted
December 4, 2017
Study Start
April 8, 2017
Actual (reported)Primary Completion
July 29, 2017
Actual (reported)Contact the study team to confirm eligibility.
Study Completion
January 23, 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
December 5, 2017
Record last verified: 2017-12
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Source: ClinicalTrials.gov.
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