The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort

NCT03356262 | Active Not Recruiting

• 1 other identifier: QUALITY
• Study Type: observational
• Target: 630
• Locations: 0 countries
• Sites: N/A

Brief Summary

The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and determinants of childhood obesity and its cardiometabolic consequences.

Conditions

Obesity, Childhood; Diabetes Mellitus, Type 2; Cardiovascular Risk Factor; Pediatric ALL; Lifestyle; Physical Activity; Sedentary Lifestyle; Diet Habit; Metabolic Complication

Keywords

Cohort study

Outcome Measures

Primary Outcomes (1)

• Body mass index (BMI)

  Weight (kg) and height (m) will be combined to report BMI in kg/m\^2 and transformed to z-scores using WHO standards

  Through study completion, 13 - 14 years post baseline

Secondary Outcomes (8)

• Waist circumference

  Through study completion, 13 - 14 years post baseline

• % body fat mass

  Through study completion, 13 - 14 years post baseline

• Impaired fasting glucose

  Through study completion, 13 - 14 years post baseline

• Impaired glucose tolerance

  Through study completion, 13 - 14 years post baseline

• Type 2 diabetes

  Through study completion, 13 - 14 years post baseline

Eligibility Criteria

• Age: 8 Years - 10 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

630 Caucasian families with a child aged 8-10 years agreed to participate and completed the baseline evaluation. 564 families completed the second round of data collection 2 years later. 377 families completed the third round of data collection 7 years after the baseline assessment. A 4th round of data collection is currently being prepared.

You may qualify if:

• Children aged 8-10 years at baseline;
• Caucasian of Western European ancestry;
• At least one obese biological parent (i.e., body mass index (BMI) ≥30 kg/m2 or waist circumference \>102 cm in men and \>88 cm in women, based on self-reported measurements of height, weight and waist circumference)
• Both biological parents available to participate in the baseline assessment.

You may not qualify if:

• Children with a previous diagnosis of Type 1 or 2 diabetes;
• Children with a previous diagnosis of a serious illness, psychological condition, or cognitive disorder which hindered participation in some or all of the study components;
• Children treated with anti-hypertensive medication or steroids (except if administered topically or through inhalation);
• Children following a very restricted diet (\< 600 kcal/day);
• Mother pregnant or breastfeeding at the baseline evaluation;
• Family with pending plans to move out of the province of Quebec (Canada).

Sponsors & Collaborators

• St. Justine's Hospital: lead

Related Publications (8)

• Lambert M, Van Hulst A, O'Loughlin J, Tremblay A, Barnett TA, Charron H, Drapeau V, Dubois J, Gray-Donald K, Henderson M, Lagace G, Low NC, Mark S, Mathieu ME, Maximova K, McGrath JJ, Nicolau B, Pelletier C, Poirier P, Sabiston C, Paradis G. Cohort profile: the Quebec adipose and lifestyle investigation in youth cohort. Int J Epidemiol. 2012 Dec;41(6):1533-44. doi: 10.1093/ije/dyr111. Epub 2011 Jul 23. No abstract available.

  PMID: 21785124 BACKGROUND

• Saade MB, Holden S, Kakinami L, McGrath JJ, Mathieu ME, Poirier P, Barnett TA, Beaucage P, Henderson M. Adiposity and cardiac autonomic function in children with a family history of obesity. Clin Auton Res. 2024 Dec;34(6):583-592. doi: 10.1007/s10286-024-01063-y. Epub 2024 Sep 21.

  PMID: 39304555 DERIVED

• Harnois-Leblanc S, Van Hulst A, Lucibello KM, Harbec MJ, Sabiston CM, Maximova K, Sylvestre MP, Henderson M. Associations Between Weight-Loss Attempts, Weight-Related Stress, and Body Image During Childhood and Adolescence in Children With Parental Obesity. Child Obes. 2024 Sep;20(6):434-441. doi: 10.1089/chi.2023.0082. Epub 2024 Jan 19.

  PMID: 38241489 DERIVED

• Sohi DK, Van Hulst A, McNealis V, Simoneau G, Drapeau V, Barnett TA, Mathieu ME, Paradis G, Tremblay A, Benedetti A, Henderson M. Early Lifestyle Determinants of Adiposity Trajectories from Childhood into Late Adolescence. Child Obes. 2024 Jul;20(5):336-345. doi: 10.1089/chi.2023.0062. Epub 2023 Dec 13.

  PMID: 38100098 DERIVED

• Roberge JB, Harnois-Leblanc S, McNealis V, van Hulst A, Barnett TA, Kakinami L, Paradis G, Henderson M. Body Mass Index Z Score vs Weight-for-Length Z Score in Infancy and Cardiometabolic Outcomes at Age 8-10 Years. J Pediatr. 2021 Nov;238:208-214.e2. doi: 10.1016/j.jpeds.2021.07.046. Epub 2021 Jul 21.

  PMID: 34302856 DERIVED

• Van Hulst A, Paradis G, Harnois-Leblanc S, Benedetti A, Drapeau V, Henderson M. Lowering Saturated Fat and Increasing Vegetable and Fruit Intake May Increase Insulin Sensitivity 2 Years Later in Children with a Family History of Obesity. J Nutr. 2018 Nov 1;148(11):1838-1844. doi: 10.1093/jn/nxy189.

  PMID: 30383280 DERIVED

• Roberge JB, Van Hulst A, Barnett TA, Drapeau V, Benedetti A, Tremblay A, Henderson M. Lifestyle Habits, Dietary Factors, and the Metabolically Unhealthy Obese Phenotype in Youth. J Pediatr. 2019 Jan;204:46-52.e1. doi: 10.1016/j.jpeds.2018.08.063. Epub 2018 Oct 23.

  PMID: 30366774 DERIVED

• Van Hulst A, Paradis G, Benedetti A, Barnett TA, Henderson M. Pathways Linking Birth Weight and Insulin Sensitivity in Early Adolescence: A Double Mediation Analysis. J Clin Endocrinol Metab. 2018 Dec 1;103(12):4524-4532. doi: 10.1210/jc.2018-00525.

  PMID: 30137396 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Plasma, blood, serum, urine, stool, saliva

MeSH Terms

Conditions

Pediatric Obesity; Diabetes Mellitus, Type 2; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Motor Activity; Sedentary Behavior; Feeding Behavior

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Leukemia, Lymphoid; Leukemia; Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Behavior; Behavior, Animal

Study Officials

• Melanie Henderson, MD, PhD

  Université de Montréal

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical assistant professor

Study Record Dates

• First Submitted: November 11, 2017
• First Posted: November 29, 2017
• Study Start: July 25, 2005
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2030
• Last Updated: December 2, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share