Early-onset Pneumonia After Out-of-hospital Cardiac Arrest
PP-ACR
Impact of Early Diagnosis Algorithm for Early-onset Pneumonia Diagnosis on Prognosis of Patients With Out-of-hospital Cardiac Arrest
1 other identifier
observational
240
1 country
1
Brief Summary
Early-onset pneumonia after out-of-hospital cardiac arrest is frequent. An association between early-onset pneumonia and an increase in morbidity has been reported in this population. The diagnosis of early-onset pneumonia inpatients with out-of-hospital cardiac arrest may be challenging as diagnosis criteria are unspecific in this setting. On the other hand some studies have reported an association between early antibiotics and better prognosis in patients with out-of-hospital cardiac arrest suggesting that early diagnosis and treatment of pneumonia would benefit to patients. Nonetheless, adminitration of antibiotics to any patients with out-of-hospital cardiac arrest would expose to antibiotic patients without infection and woould participate to increase in antibiotic resistance. Therefore, the PP-ACR study aims to evaluate the impact of a diagnosis algorithm including blinded sampling protected brushes on early-onset pneumonia treatment and patient prognosis after out-of-hospital cardiac arrest.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2016
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 3, 2016
CompletedFirst Submitted
Initial submission to the registry
November 23, 2017
CompletedFirst Posted
Study publicly available on registry
November 28, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 31, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2018
CompletedNovember 29, 2017
October 1, 2017
1.7 years
November 23, 2017
November 28, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
delay between intensive care admission and antibiotic initiation
first 5 days
delta respiratory SOFA score between Day 1 and day 3
first 3 days
Eligibility Criteria
patients admitted for out-of-hospital cardiac arrest in intensive care who and treated with hypothermia
You may qualify if:
- patients admitted for out-of-hospital cardiac arrest and treated with hypothermia
You may not qualify if:
- age less than 18
- consent withdrawal
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
CHRU de Brest
Brest, 29609, France
Related Publications (1)
Lemee P, Chapalain X, Bailly P, Sparrow RL, Jean-Michel V, Prat G, Renault A, Tonnelier JM, Aubron C. PROACTIVE SCREENING ALGORITHM FOR EARLY-ONSET PNEUMONIA IN PATIENTS WITH OUT-OF-HOSPITAL CARDIAC ARREST: A BEFORE-AFTER IMPLEMENTATION STUDY. Shock. 2024 Jul 1;62(1):13-19. doi: 10.1097/SHK.0000000000002347. Epub 2024 Mar 25.
PMID: 38661180DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 23, 2017
First Posted
November 28, 2017
Study Start
October 3, 2016
Primary Completion
May 31, 2018
Study Completion
July 1, 2018
Last Updated
November 29, 2017
Record last verified: 2017-10
Data Sharing
- IPD Sharing
- Will not share