The Effect of Psyllium Fibre on LDL-C, Non-HDL-C, and Apolioprotein-B: A Systematic Review and Meta-analysis
The Effect of Psyllium Fibre (Plantago Ovata) on LDL-cholesterol and Emerging Lipid Targets, Non-HDL-cholesterol and Apolioprotein-B: A Systematic Review and Meta-analysis of Randomized Controlled Trials
1 other identifier
observational
1,000
0 countries
N/A
Brief Summary
Serum cholesterol is a major modifiable risk factor for cardiovascular disease, which despite considerable reduction in prevalence, remains the leading cause of premature mortality worldwide. Although LDL-C continues to be recognized as the primary therapeutic target, accumulating evidence suggests that alternative lipid parameters, non-HDL-C and apoB, may provide predictive value beyond that of LDL-C alone, in most population categories. Numerous lifestyle strategies have been developed to manage elevated cholesterol concentrations, of which viscous fibre is often encouraged for its beneficial effects on LDL-C reduction. Conversely, the effects of viscous fibre on new lipid markers, non-HDL and apoB, have yet to be defined. Therefore, this study seeks to elucidate the therapeutic potential of psyllium fibre on totality of atherogenic cholesterol and lipoprotein particles in a systematic review and meta-analysis of randomized controlled trials.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2013
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 8, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2017
CompletedFirst Submitted
Initial submission to the registry
November 15, 2017
CompletedFirst Posted
Study publicly available on registry
November 17, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2017
CompletedNovember 17, 2017
November 1, 2017
4.1 years
November 15, 2017
November 15, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
LDL-Cholesterol
>= 3 months
non-HDL cholesterol
>= 3 months
Apolipoprotein-B
>= 3 months
Interventions
Viscous soluble psyllium fibre
Eligibility Criteria
Hypercholesterolemic or normocholesterolemic children and adults, overweight and obese individuals or individuals with diabetes
You may qualify if:
- human trials
- RCT that investigates the effect of psyllium fibre on LDL-C, non-HDL-C and/or apoB
- suitable control
- minimum follow up period ≥ 3 weeks
- amount of psyllium fibre must be report and effect on outcomes isolatable
You may not qualify if:
- follow up \< 3 weeks
- non-human trials
- lack of suitable control
- no viable endpoint data
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Jovanovski E, Yashpal S, Komishon A, Zurbau A, Blanco Mejia S, Ho HVT, Li D, Sievenpiper J, Duvnjak L, Vuksan V. Effect of psyllium (Plantago ovata) fiber on LDL cholesterol and alternative lipid targets, non-HDL cholesterol and apolipoprotein B: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2018 Nov 1;108(5):922-932. doi: 10.1093/ajcn/nqy115.
PMID: 30239559DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 15, 2017
First Posted
November 17, 2017
Study Start
October 8, 2013
Primary Completion
November 1, 2017
Study Completion
December 1, 2017
Last Updated
November 17, 2017
Record last verified: 2017-11