Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients

NCT03342820 | Completed

• 2 other identifiers: 2016_502017_A01605-48
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluates the effects of an isokinetic fatigue protocol of the quadriceps on the amount of co-contractions of this last with the hamstrings during a maximal isometric flexion movement in hemiparetic stroke patients. The effect of such a protocol on gait parameters and spasticity of the quadriceps will be evaluated also.

Conditions

Stroke; Spasticity, Muscle; Muscle Fatigue; Gait, Hemiplegic

Outcome Measures

Primary Outcomes (1)

• Cocontraction Index (CCI) between the rectus femoris and the semitendinosus

  ratio of the RMS of a the rectus femoris when acting as antagonist to the effort intended (knee flexion) to the RMS of the same muscle when acting as an agonist during a reciprocal maximal isometric knee flexion effort (500 ms around the peak of rectified EMG

  one day

Secondary Outcomes (11)

• Cocontraction Index (CCI) between the other parts of the quadriceps and the semitendinosus muscle

  one day

• Agonist Recruitment Index of the semitendinosus

  one day

• Isometric peak knee flexion torque

  one day

• Spasticity of the quadriceps

  one day

• spatio-temporal gait parameters at comfortable speed

  one day

Study Arms (1)

Quadriceps muscle fatigue

EXPERIMENTAL

Quadriceps muscle fatigue

Procedure: Muscle fatigue

Interventions

Muscle fatigue PROCEDURE

Isokinetic quadriceps muscle fatigue of the paretic lower limb

Quadriceps muscle fatigue

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age between 18 and 80y
• Hemiparesis after a first-ever stroke \> 3 months
• Spasticity of the quadriceps muscle
• Quadriceps strength at least at 3/5 (MRC testing)
• Subject able to walk at least 2min without rest
• Informed consent
• Social security affiliation

You may not qualify if:

• Severe comprehension troubles (language, cognitive or psychiatric disorders)
• History of previous stroke, locomotor or other neurological disorders
• Locomotor troubles affecting the paretic arm
• Contraindication to efforts : cardiac insufficiency, severe aortic valvular stenosis, recent heart failure, non treated high blood pressure, severe peripheral arterial disease
• Pregnancy or breastfeeding
• Adult subject to guardianship

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hôpital Swynghedauw, CHU

Lille, France

Location

MeSH Terms

Conditions

Stroke; Muscle Spasticity; Gait Disorders, Neurologic

Interventions

Muscle Fatigue

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Muscular Diseases; Musculoskeletal Diseases; Muscle Hypertonia; Neuromuscular Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Etienne Allart, Md

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 16, 2017
• First Posted: November 17, 2017
• Study Start: January 19, 2018
• Primary Completion: October 10, 2019
• Study Completion: October 10, 2019
• Last Updated: March 26, 2020

Record last verified: 2020-03

Locations

FR (1)