Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy

NCT03335696 | Completed

• 1 other identifier: MSD/IDREC/C1/2011/71
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 1

Brief Summary

Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.

Conditions

Cognitive Impairment; Dementia; Affective Disorders

Keywords

Epidemiology; Magnetic resonance imaging; Diffusion tensor imaging; White matter; Functional MRI; Connectome; Resting state brain networks; Neuropsychology

Outcome Measures

Primary Outcomes (14)

• Neuropsychological measure 1

  National Adult Reading Test (premorbid intellectual ability)

  2012-2016

• Neuropsychological measure 2

  Montreal Cognitive Assessment (MoCA)

  2012-2016

• Neuropsychological measure 3

  Rey Complex Figure copy and delayed recall (visual episodic memory)

  2012-2016

• Neuropsychological measure 4

  Hopkins Verbal Learning Test Revised (verbal episodic memory)

  2012-2016

• Neuropsychological measure 5

  CANTAB Simple and Choice Reaction Time (processing speed)

  2012-2016

• Neuropsychological measure 6

  WAIS-R Digit Symbol Test (processing speed)

  2012-2016

• Neuropsychological measure 7

  Trail Making Test A and B (processing speed/executive functioning)

  2012-2016

• Neuropsychological measure 8

  WAIS-R Digit Span forward and backwards (executive functioning)

  2012-2016

• Neuropsychological measure 9

  Graded Naming Test (semantic memory)

  2012-2016

• MRI Measures 1

  Siemens 3T - T1-weighted scan (MPRAGE) using FSL FIRST, FAST, and Freesurfer Volume extractions

  2012-2016

• MRI Measures 2

  Siemens 3T - T1-weighted scan (MPRAGE) using FSL GLM Voxel based analysis for grey matter density analysis

  2012-2016

• MRI Measures 3

  Siemens 3T - T2-weighted scan, clinical and FSL (BIANCA)-based rating of white matter changes

  2012-2016

• MRI Measures 4

  Siemens 3T Diffusion Tensor Images analyzed with Tract Based Spatial Statistics (TBSS)

  2012-2016

• MRI Measures 5

  Siemens 3T rs-fMRI analyzed with Multivariate Exploratory Linear Optimized Decomposition into Independent Components: MELODIC)

  2012-2016

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Randomly selected from phase 11 of the an occupational cohort recruited from 1985 for the Whitehall II study (Marmot M, Brunner E. Cohort Profile: the Whitehall II study. Int J Epidemiol 2005;34(2):251-6).

You may qualify if:

• Member of Whitehall II cohort attending at UCL for phase 11

You may not qualify if:

• Not suitable for MRI, travelling to Oxford, seriously physically ill

Sponsors & Collaborators

• University of Oxford: lead
• University College, London: collaborator

Study Sites (1)

University of Oxford

Oxford, England, OX3 7JX, United Kingdom

Location

Related Publications (14)

• Filippini N, Zsoldos E, Haapakoski R, Sexton CE, Mahmood A, Allan CL, Topiwala A, Valkanova V, Brunner EJ, Shipley MJ, Auerbach E, Moeller S, Ugurbil K, Xu J, Yacoub E, Andersson J, Bijsterbosch J, Clare S, Griffanti L, Hess AT, Jenkinson M, Miller KL, Salimi-Khorshidi G, Sotiropoulos SN, Voets NL, Smith SM, Geddes JR, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP. Study protocol: The Whitehall II imaging sub-study. BMC Psychiatry. 2014 May 30;14:159. doi: 10.1186/1471-244X-14-159.

  PMID: 24885374 RESULT

• Allan CL, Zsoldos E, Filippini N, Sexton CE, Topiwala A, Valkanova V, Singh-Manoux A, Tabak AG, Shipley MJ, Mackay C, Ebmeier KP, Kivimaki M. Lifetime hypertension as a predictor of brain structure in older adults: cohort study with a 28-year follow-up. Br J Psychiatry. 2015 Apr;206(4):308-15. doi: 10.1192/bjp.bp.114.153536. Epub 2014 Dec 11.

  PMID: 25497301 RESULT

• Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton CE, Mahmood A, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP. Resilience and MRI correlates of cognitive impairment in community-dwelling elders. Br J Psychiatry. 2015 Nov;207(5):435-9. doi: 10.1192/bjp.bp.114.152363. Epub 2015 Sep 3.

  PMID: 26338988 RESULT

• Allan CL, Sexton CE, Filippini N, Topiwala A, Mahmood A, Zsoldos E, Singh-Manoux A, Shipley MJ, Kivimaki M, Mackay CE, Ebmeier KP. Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort. J Affect Disord. 2016 Nov 1;204:219-25. doi: 10.1016/j.jad.2016.06.049. Epub 2016 Jun 21.

  PMID: 27372409 RESULT

• Griffanti L, Jenkinson M, Suri S, Zsoldos E, Mahmood A, Filippini N, Sexton CE, Topiwala A, Allan C, Kivimaki M, Singh-Manoux A, Ebmeier KP, Mackay CE, Zamboni G. Classification and characterization of periventricular and deep white matter hyperintensities on MRI: A study in older adults. Neuroimage. 2018 Apr 15;170:174-181. doi: 10.1016/j.neuroimage.2017.03.024. Epub 2017 Mar 15.

  PMID: 28315460 RESULT

• Suri S, Emir U, Stagg CJ, Near J, Mekle R, Schubert F, Zsoldos E, Mahmood A, Singh-Manoux A, Kivimaki M, Ebmeier KP, Mackay CE, Filippini N. Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex. Neuroimage. 2017 May 15;152:509-516. doi: 10.1016/j.neuroimage.2017.03.031. Epub 2017 Mar 18.

  PMID: 28323160 RESULT

• Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton C, Mahmood A, Fooks P, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP. Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. BMJ. 2017 Jun 6;357:j2353. doi: 10.1136/bmj.j2353.

  PMID: 28588063 RESULT

• Sexton CE, Zsoldos E, Filippini N, Griffanti L, Winkler A, Mahmood A, Allan CL, Topiwala A, Kyle SD, Spiegelhalder K, Singh-Manoux A, Kivimaki M, Mackay CE, Johansen-Berg H, Ebmeier KP. Associations between self-reported sleep quality and white matter in community-dwelling older adults: A prospective cohort study. Hum Brain Mapp. 2017 Nov;38(11):5465-5473. doi: 10.1002/hbm.23739. Epub 2017 Jul 26.

  PMID: 28745016 RESULT

• Suri S, Topiwala A, Filippini N, Zsoldos E, Mahmood A, Sexton CE, Singh-Manoux A, Kivimaki M, Mackay CE, Smith S, Ebmeier KP. Distinct resting-state functional connections associated with episodic and visuospatial memory in older adults. Neuroimage. 2017 Oct 1;159:122-130. doi: 10.1016/j.neuroimage.2017.07.049. Epub 2017 Jul 26.

  PMID: 28756237 RESULT

• Heise V, Zsoldos E, Suri S, Sexton C, Topiwala A, Filippini N, Mahmood A, Allan CL, Singh-Manoux A, Kivimaki M, Mackay CE, Ebmeier KP. Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults. PLoS One. 2017 Aug 3;12(8):e0181392. doi: 10.1371/journal.pone.0181392. eCollection 2017.

  PMID: 28771482 RESULT

• Patel R, Mackay CE, Jansen MG, Devenyi GA, O'Donoghue MC, Kivimaki M, Singh-Manoux A, Zsoldos E, Ebmeier KP, Chakravarty MM, Suri S. Inter- and intra-individual variation in brain structural-cognition relationships in aging. Neuroimage. 2022 Aug 15;257:119254. doi: 10.1016/j.neuroimage.2022.119254. Epub 2022 Apr 28.

  PMID: 35490915 DERIVED

• Jansen MG, Griffanti L, Mackay CE, Anaturk M, Melazzini L, Lange AG, Filippini N, Zsoldos E, Wiegertjes K, Leeuw FE, Singh-Manoux A, Kivimaki M, Ebmeier KP, Suri S. Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life. J Cereb Blood Flow Metab. 2022 Apr;42(4):600-612. doi: 10.1177/0271678X211048411. Epub 2021 Oct 5.

  PMID: 34610763 DERIVED

• Suri S, Chiesa ST, Zsoldos E, Mackay CE, Filippini N, Griffanti L, Mahmood A, Singh-Manoux A, Shipley MJ, Brunner EJ, Kivimaki M, Deanfield JE, Ebmeier KP. Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study. PLoS Med. 2020 Dec 29;17(12):e1003467. doi: 10.1371/journal.pmed.1003467. eCollection 2020 Dec.

  PMID: 33373359 DERIVED

• Zsoldos E, Mahmood A, Filippini N, Suri S, Heise V, Griffanti L, Mackay CE, Singh-Manoux A, Kivimaki M, Ebmeier KP. Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study. Brain Commun. 2020 Mar 7;2(1):fcaa026. doi: 10.1093/braincomms/fcaa026. eCollection 2020.

  PMID: 32954286 DERIVED

Related Links

• Whitehall Imaging Oxford

Biospecimen

Retention: SAMPLES WITH DNA

White cells, buccal swabs

MeSH Terms

Conditions

Cognitive Dysfunction; Dementia; Mood Disorders

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Klaus P Ebmeier, MD

  University of Oxford

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 29, 2017
• First Posted: November 8, 2017
• Study Start: January 1, 2012
• Primary Completion: June 30, 2017
• Study Completion: June 30, 2017
• Last Updated: December 5, 2023

Record last verified: 2017-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: After 2019
• Access Criteria: approval by data sharing committee

Locations

GB (1)