NCT03334474

Brief Summary

The process of population aging that is occurring in developed societies represents a major challenge for the health system. The aim of this study is to analyze factors that have an influence on early vascular aging (EVA), estimated by carotid-femoral pulse wave velocity (cf-PWV) and Cardio Ankle Vascular Index (CAVI), and to determine differences by gender in a Chinese population.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2018

Typical duration for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 3, 2017

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 7, 2017

Completed
3 months until next milestone

Study Start

First participant enrolled

February 1, 2018

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2021

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2021

Completed
Last Updated

November 7, 2017

Status Verified

November 1, 2017

Enrollment Period

3 years

First QC Date

November 3, 2017

Last Update Submit

November 3, 2017

Conditions

Vascular Diseases

Outcome Measures

Primary Outcomes (1)

  • Cardio-ankle vascular index

    This parameter will be estimated using Vasera device VS-1500.

    2 years

Study Arms (3)

young

18-35 years old

middle

35-65 years old

aged

65-85 years old

Eligibility Criteria

Age18 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Study population It will be the urban population attached to the Health Center of Shanghai. Using a random sampling stratified by age groups and gender, 300 subjects will be selected in each group (150 males and 150 females), aged 35 to 85 years.

You may not qualify if:

  • Subjects who are in terminal condition, who cannot travel to the health centers to undergo the corresponding examinations, and those who do not wish to sign the informed consent.
  • Subjects with a history of CVD (ischemic heart disease or stroke, peripheral arterial disease or heart failure), diagnosed renal failure in terminal stages (glomerular filtration rate below 30%), chronic inflammatory disease, or acute inflammatory process in the past three months.
  • Patients treated with estrogens, testosterone, or growth hormone.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Vascular Diseases

Condition Hierarchy (Ancestors)

Cardiovascular Diseases

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Study Record Dates

First Submitted

November 3, 2017

First Posted

November 7, 2017

Study Start

February 1, 2018

Primary Completion

February 1, 2021

Study Completion

May 1, 2021

Last Updated

November 7, 2017

Record last verified: 2017-11

Data Sharing

IPD Sharing
Will not share