Stress Urinary Incontinence in Women With Multiple Sclerosis

NCT03332654 | Completed

• 1 other identifier: OBS-019
• Study Type: observational
• Target: 363
• Locations: 0 countries
• Sites: N/A

Brief Summary

Objective: To report the prevalence and risk factors of stress urinary incontinence (SUI) and the prevalence of intrinsic sphincter deficiency in women with multiple sclerosis (MS). Methods: A retrospective study was conducted among Female patients with MS, followed for lower urinary tract symptoms (LUTS) during a 15-year period. Demographic data, MS history, expanded disability status scale (EDSS) score at the urodynamic visit, obstetrical past, birth weight, LUTS, and urodynamic findings were collected. SUI was defined as incontinence during cough, or any effort. A maximum urethral closure pressure less than 30 cm H2O defined intrinsic sphincter deficiency. Results: In total 363 women with a mean age of 46.7±10.8 years and a mean disease duration of 12.9±8.7 years were included. The incidence of relapsing remitting MS, a secondary progressive form, and a primary progressive form was 60.6%, 32.8%, and 6.6%, respectively. The prevalence of SUI was 31.4%. The prevalence of intrinsic sphincter deficiency was 1.4% and 0.8% of these patients had a SUI (P=0.300). In a multivariate analysis, women with a SUI had significantly higher birth weight (P=0.030), a pelvic organ prolapse (P=0.021), urgent urinary incontinence (P=0.006), a lower EDSS score (P=0.019), and a weaker containing effort (P\<0.001). Conclusions: The prevalence of SUI in women with MS was 31.4%. This symptom could affect the quality of life of women with MS.

Conditions

Urinary Incontinence, Stress; Multiple Sclerosis

Keywords

Urinary Incontinence, Stress; Multiple Sclerosis; Lower Urinary Tract Symptoms

Outcome Measures

Primary Outcomes (1)

• Stress urinary incontinence

  at inclusion

Study Arms (1)

Multiple sclerosis

Prevalence and risk factor of stress urinary incontinence in women with multiple sclerosis and included in the database over 15 years from December 1999 to June 2014, who had undergone a urodynamic test

Other: Determine prevalence of stress urinary incontinence

Interventions

Determine prevalence of stress urinary incontinence OTHER

Multiple sclerosis

Eligibility Criteria

• Age: 18 Years+
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All women aged \>18 years with multiple sclerosis, who had undergone a urodynamic test for lower urinary tract symptoms were included

You may qualify if:

• Women aged \>18 years
• Multiple sclerosis
• Urodynamic test for lower urinary tract symptoms
• Followed in Saint Philibert Hospital between December 1999 to June 2014

You may not qualify if:

• Non confirmation of diagnosis of Multiple sclerosis

Sponsors & Collaborators

• Lille Catholic University: lead

MeSH Terms

Conditions

Urinary Incontinence, Stress; Multiple Sclerosis; Lower Urinary Tract Symptoms

Condition Hierarchy (Ancestors)

Urinary Incontinence; Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Cecile Donzé, MD

  GHICL

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 2, 2017
• First Posted: November 6, 2017
• Study Start: February 1, 2015
• Primary Completion: January 31, 2016
• Study Completion: March 31, 2016
• Last Updated: November 6, 2017

Record last verified: 2017-11