NCT03327454

Brief Summary

The main aim of this study is to ascertain general satisfaction among participants with rheumatic diseases with day-to-day use of the Benepali® prefilled pen by means of a standardised participant questionnaire. In addition, it is to be investigated whether differences exist in general participant satisfaction between participant groups who have undergone various prior treatment and/or have previous experience with application systems (participants new to the use of biologics, participants changing over from a prefilled injection or changing over from another pre-filled pen) and between participants of the various indication groups. Furthermore, the participants are to evaluate various aspects of using the Benepali® pre-filled pen based on their personal experience, such as e.g. handling, user-friendliness and features of the Benepali® pre-filled pen, as well as the effectiveness of the training on injection with the Benepali® pre-filled pen, based on participant satisfaction with the training received with the training pen and the evaluation of the training material received.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2017

Shorter than P25 for all trials

Geographic Reach
1 country

38 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 10, 2017

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

October 11, 2017

Completed
20 days until next milestone

First Posted

Study publicly available on registry

October 31, 2017

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 21, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 21, 2018

Completed
Last Updated

October 23, 2018

Status Verified

October 1, 2018

Enrollment Period

11 months

First QC Date

October 11, 2017

Last Update Submit

October 22, 2018

Conditions

Keywords

Ankylosing spondylitisAxial spondyloarthritisBenepali penEtanerceptPatient questionnairePre-filled penBiological DMARDsAntirheumatic drug

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants that are "Very Satisfied (4)" or "Satisfied (3)" with the Benepali Pre-Filled Pen

    The Questionnaire is based on a 5-point Likert scale where 0 = very dissatisfied, 1 = dissatisfied, 2 = neither dissatisfied nor satisfied, 3 = satisfied, 4 = very satisfied.

    Day 1

Secondary Outcomes (2)

  • Percentage of Participants that Answered Questions on Their Personal Experience of Various Aspects of Using the Benepali Pre-Filled Pen with a (3) or (4) on a 5-point Likert Scale.

    Day 1

  • Percentage of Participants that Answered "Yes" in Terms of Satisfaction with Training Materials

    Day 1

Study Arms (1)

Benepali

Treatment of participants with the Benepali pre-filled pen takes place in accordance with the prescribing information and standard medical practice.

Biological: Benepali

Interventions

BenepaliBIOLOGICAL

Administered as specified in the treatment arm.

Also known as: Etanercept
Benepali

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants who are treated by practitioners in Germany and who are eligible according to the inclusion/exclusion criteria.

You may qualify if:

  • Diagnosis of moderate to severe active rheumatoid arthritis, severe active and progressive rheumatoid arthritis, active and progressive psoriatic arthritis, severe active ankylosing spondylitis, or severe non-radiographic axial spondyloarthritis
  • Current treatment with the Benepali® pre-filled pen in accordance with prescribing information for at least 3 months beforehand
  • The patient has signed a declaration of consent to take part in the study

You may not qualify if:

  • Patients who are receiving Benepali® for the treatment of moderate to severe plaque psoriasis
  • Patients who exhibit contraindications in accordance with the prescribing information for Benepali® and therefore treatment with Benepali ® is not indicated

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (38)

Research Site

Altenholz, 24161, Germany

Location

Research Site

Bad Neuenahr-Ahrweiler, 53474, Germany

Location

Research Site

Berlin, 10117, Germany

Location

Research Site

Berlin, 10719, Germany

Location

Research Site

Berlin, 12435, Germany

Location

Research Site

Berlin, 12555, Germany

Location

Research Site

Berlin, 13055, Germany

Location

Research Site

Berlin, 13353, Germany

Location

Research Site

Braunschweig, 38100, Germany

Location

Research Site

Coburg, 96450, Germany

Location

Research Site

Cologne, 50825, Germany

Location

Research Site

Dresden, 01109, Germany

Location

Research Site

Düsseldorf, 40211, Germany

Location

Research Site

Ehringshausen, 35630, Germany

Location

Research Site

Erfurt, 99096, Germany

Location

Research Site

Essen, 45326, Germany

Location

Research Site

Giessen, 35392, Germany

Location

Research Site

Göpping, 73033, Germany

Location

Research Site

Halle, 06128, Germany

Location

Research Site

Hamburg, 22767, Germany

Location

Research Site

Homburg, 66424, Germany

Location

Research Site

Jülich, 52428, Germany

Location

Research Site

Kronach, 96317, Germany

Location

Research Site

Leipzig, 04109, Germany

Location

Research Site

Leipzig, 04129, Germany

Location

Research Site

Ludwigshafen, 67069, Germany

Location

Research Site

Magdeburg, 39104, Germany

Location

Research Site

Mansfeld, 06343, Germany

Location

Research Site

Mittelherwigsdorf, 02763, Germany

Location

Research Site

München, 80639, Germany

Location

Research Site

Neuss, 41462, Germany

Location

Research Site

Norderstedt, 22844, Germany

Location

Research Site

Nuremberg, 90443, Germany

Location

Research Site

Offenberg, 77652, Germany

Location

Research Site

Saarbrücken, 66111, Germany

Location

Research Site

Seesen, 38723, Germany

Location

Research Site

Tübingen, 72072, Germany

Location

Research Site

Ulm, 89073, Germany

Location

MeSH Terms

Conditions

Arthritis, RheumatoidSpondylarthropathiesSpondylitis, AnkylosingAxial Spondyloarthritis

Interventions

Etanercept

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System DiseasesSpondylarthritisSpondylitisSpinal DiseasesBone DiseasesAnkylosis

Intervention Hierarchy (Ancestors)

Immunoglobulin Fc FragmentsImmunoglobulin FragmentsPeptide FragmentsPeptidesAmino Acids, Peptides, and ProteinsImmunoglobulin Constant RegionsImmunoglobulinsImmunoproteinsBlood ProteinsProteinsSerum GlobulinsGlobulinsReceptors, Tumor Necrosis FactorReceptors, CytokineReceptors, ImmunologicReceptors, Cell SurfaceMembrane Proteins

Study Officials

  • Medical Director

    Biogen

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
CROSS SECTIONAL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 11, 2017

First Posted

October 31, 2017

Study Start

August 10, 2017

Primary Completion

June 21, 2018

Study Completion

June 21, 2018

Last Updated

October 23, 2018

Record last verified: 2018-10

Data Sharing

IPD Sharing
Will not share

Locations