Effectiveness of Bronchoscopic Interventions for Malignant Airway Obstruction
Comparative Effectiveness of Bronchoscopic Interventions for Malignant Airway Obstruction
2 other identifiers
observational
110
1 country
1
Brief Summary
The goal of this clinical research study is learn about side effects and the success of bronchoscopies when performed in cancer patients with and without symptoms. This is an investigational study. Up to 110 patients will take part in this study. All will be enrolled at MD Anderson.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 25, 2011
CompletedFirst Submitted
Initial submission to the registry
October 20, 2017
CompletedFirst Posted
Study publicly available on registry
October 31, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2019
CompletedApril 16, 2019
April 1, 2019
7.6 years
October 20, 2017
April 11, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Time to Any Complication Requiring Treatment
Researchers will estimate the hazard function of time to any complications in the framework of competing risks while death is the competing risk.3 Researchers will graphically visualize the hazard function of time to any complications using Kernel smoothing method.
2 years
Secondary Outcomes (1)
Quality-Adjusted Survival
2 years
Other Outcomes (2)
Early Intervention
2 years
Late Intervention
2 years
Study Arms (1)
Bronchoscopy Data Collection
Medical information collected after bronchoscopy for up to 2 years.
Interventions
Medical information collected after bronchoscopy for up to 2 years.
Eligibility Criteria
Participants scheduled for standard of care bronchoscopy at UT MD Anderson Cancer Center in Houston, Texas.
You may qualify if:
- ° All patients undergoing interventional bronchoscopy during the first 12 months will be enrolled, with follow-up occurring out to 2 years from the study startup (the duration of the grant).
You may not qualify if:
- Age less than 18 years,
- Inability to participate in telephone follow-up
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
Related Publications (1)
Ong P, Grosu HB, Debiane L, Casal RF, Eapen GA, Jimenez CA, Noor L, Ost DE. Long-term quality-adjusted survival following therapeutic bronchoscopy for malignant central airway obstruction. Thorax. 2019 Feb;74(2):141-156. doi: 10.1136/thoraxjnl-2018-211521. Epub 2018 Sep 25.
PMID: 30254139DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David Ost, MD
M.D. Anderson Cancer Center
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 20, 2017
First Posted
October 31, 2017
Study Start
August 25, 2011
Primary Completion
April 1, 2019
Study Completion
April 1, 2019
Last Updated
April 16, 2019
Record last verified: 2019-04