Resistance Training and Cardiometabolic Health

NCT03325933 | Terminated

• 1 other identifier: STUDY00006617
• Study Type: interventional
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the relationship between resistance training load and repetitions on cardiometabolic outcomes. The primary objective of this clinical trial is to determine whether high load or low load resistance exercise training affects arterial stiffness in overweight or obese men and women. Our secondary objectives are to investigate the effects of high and low load RT on vascular function, cardiac structure, and markers of insulin sensitivity. Finally, we are going to preliminarily explore the effects of resistance training on intestinal bacteria.

Conditions

Insulin Sensitivity; Endothelial Dysfunction; Blood Pressure

Keywords

insulin sensitivity; muscle; strength; resistance training; strength training; vascular function; arterial stiffness; glucose tolerance

Outcome Measures

Primary Outcomes (1)

• Arterial Stiffness

  Measured via pulse wave velocity

  Change from Baseline Pulse Wave Velocity at 12 weeks

Secondary Outcomes (11)

• Insulin Sensitivity

  Change from Baseline Matsuda Index at 12 weeks

• Endothelial Function

  Change from Baseline %FMD at 12 weeks

• Cardiac echocardiography

  Changes in systolic and diastolic parameters from baseline to 12 weeks

• Isokinetic Strength

  Change from Baseline isokinetic strength at 12 weeks

• Isometric Strength

  Change from Baseline Isometric strength at 12 weeks

Other Outcomes (1)

• Maximal Oxygen Consumption

  Change from Baseline VO2peak at 12 weeks

Study Arms (3)

Resistance Training 1

EXPERIMENTAL

Participants will perform resistance training with high training loads and low repetitions (high load/low rep resistance training).

Other: High Load/Low Rep Resistance Training

Resistance Training 2

EXPERIMENTAL

Participants will perform resistance training with low training loads and high repetitions (Low load/high rep resistance training).

Other: Low Load/High Rep Resistance Training

Wait-list control

NO INTERVENTION

This group will be offered the option of participating in either experimental group after the study is completed.

Interventions

High Load/Low Rep Resistance Training OTHER

Participants will be prescribed High Load/Low Rep resistance training.

Resistance Training 1

Low Load/High Rep Resistance Training OTHER

Participants will be prescribed Low Load/High Rep resistance training.

Resistance Training 2

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male and female
• years of age
• BMI 25-40
• No recent history of starting a structured exercise program or diet in the last 3 months

You may not qualify if:

• Current smoker and/or recreational drug user
• Answers "yes" to one or more questions on the Physical Activity Readiness Questionnaire
• Diagnosed diabetes, heart disease
• History of anabolic steroid use in the past six months
• Taking medications for treatment of diabetes, heart disease, and hypertension.
• Orthopedic or musculoskeletal contraindications to resistance training
• Unwilling to follow any aspect of the study protocol including blood sampling and weight training

Sponsors & Collaborators

• Arizona State University: lead

Study Sites (1)

Arizona State University

Phoenix, Arizona, 85004, United States

Location

Related Publications (43)

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MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Siddhartha S Angadi, PhD

  Arizona State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: October 13, 2017
• First Posted: October 30, 2017
• Study Start: September 21, 2017
• Primary Completion: August 31, 2020
• Study Completion: August 31, 2020
• Last Updated: April 19, 2021

Record last verified: 2021-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)