Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Hemodynamics and Vascular Function

NCT03225898 | Unknown

• 1 other identifier: 17-285
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The American College of Sports Medicine (ACSM) recommends that resistance exercise performed at greater than 70% one repetition maximum (1 RM) is necessary to induce strength gains and muscular hypertrophy (ACSM, 2009). However, previous work has shown resistance exercise at high intensity increases the rate of injury. Blood flow restriction (BFR) exercise is a method that is used to compress the blood vessels to the exercising muscle in order to reduce blood flow to the limb with the use of low-intensity resistance. Researchers have suggested that resistance exercise at intensities as low as 20-30% 1-repetition maximum with BFR increases in muscle mass, muscular endurance, and gains in strength. However, the acute heart and blood vessel changes in response to BFR are not clear. Work by our laboratory (Tai et al., 2016) has demonstrated that immediately following acute resistance exercise at moderate intensity (75% 1 RM) without BFR, there are no changes in aortic and brachial systolic and diastolic blood pressure (BP), but there are increases in the pressure of the reflective wave (augmentation pressure). This suggests that the arterial wall is stiff, and may in turn result in thickening of the arterial wall. However, the data are limited and these responses may not be universally accepted. In addition, these studies used primarily lower-body resistance exercises (squat, leg extension, and leg flexion), and did not assess changes in heart and blood vessel function. Previous researchers have demonstrated that upper-body exercise induces higher BP and heart rate (HR) than lower-body exercise. However, the effects of upper- and lower-body resistance exercise with BFR on heart and blood vessel function are still unclear. Therefore, understanding the effects of upper- and lower-body resistance exercise with BFR on heart and blood vessel function using weight machines, specifically the chess press, latissimus dorsi pulldown, knee extension, and knee flexion may significant impact how the resistance training program is prescribed.

Conditions

Endothelial Dysfunction; Autonomic Dysfunction

Keywords

blood flow restriction; resistance exercise

Outcome Measures

Primary Outcomes (1)

• Change from Baseline Autonomic Modulation over 1 hour

  Heart rate variability

  Rest, 10 min, 20 min, 30 min, 40 min, 50 min, 60 min post exercise

Secondary Outcomes (1)

• Change from Baseline Endothelial Function over 1 hour

  Rest, 10 min, 20 min, 30 min, 40 min, 50 min, 60 min post exercise

Study Arms (2)

Resistance Exercise with Blood flow restriction

EXPERIMENTAL

Subjects will perform 4 sets with 30, 15, 15, 15 repetitions at 30% 1RM.

Other: Resistance Exercise with Blood Flow Restriction

High-intensity resistance exercise

ACTIVE COMPARATOR

Subjects will perform 4 sets of 8 repetitions at 70% 1RM.

Other: High-intensity Resistance Exercise

Interventions

Resistance Exercise with Blood Flow Restriction OTHER

A cuff will be used to restrict blood flow to the extremities.

Also known as: KATTSU

Resistance Exercise with Blood flow restriction

High-intensity Resistance Exercise OTHER

Participants will follow a conventional resistance exercise regime.

High-intensity resistance exercise

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• days per week of resistance training for 1 year
• years of age

You may not qualify if:

• include a recent smoking history (\< 6 months)
• obesity (defined as a body mass index ≥ 30 kg/m2)
• skeletal and orthopedic injuries
• cancer
• known cardiovascular disease
• open wounds
• history of blood clots
• metabolic disease
• uncontrolled hypertension (resting brachial BP ≥ 140/90 mmHg)
• pregnancy, planning to get pregnant
• taking any medications or supplements known to affect blood pressure, heart rate, or vascular function

Sponsors & Collaborators

• Kent State University: lead

Study Sites (1)

Cardiovascular Dynamics Laboratory

Kent, Ohio, 44242, United States

RECRUITING

Related Publications (4)

• Madarame H, Neya M, Ochi E, Nakazato K, Sato Y, Ishii N. Cross-transfer effects of resistance training with blood flow restriction. Med Sci Sports Exerc. 2008 Feb;40(2):258-63. doi: 10.1249/mss.0b013e31815c6d7e.

  PMID: 18202577 BACKGROUND

• Takarada Y, Sato Y, Ishii N. Effects of resistance exercise combined with vascular occlusion on muscle function in athletes. Eur J Appl Physiol. 2002 Feb;86(4):308-14. doi: 10.1007/s00421-001-0561-5.

  PMID: 11990743 BACKGROUND

• Rossow LM, Fahs CA, Sherk VD, Seo DI, Bemben DA, Bemben MG. The effect of acute blood-flow-restricted resistance exercise on postexercise blood pressure. Clin Physiol Funct Imaging. 2011 Nov;31(6):429-34. doi: 10.1111/j.1475-097X.2011.01038.x. Epub 2011 Jul 7.

  PMID: 21981453 BACKGROUND

• Figueroa A, Vicil F. Post-exercise aortic hemodynamic responses to low-intensity resistance exercise with and without vascular occlusion. Scand J Med Sci Sports. 2011 Jun;21(3):431-6. doi: 10.1111/j.1600-0838.2009.01061.x. Epub 2010 Jan 31.

  PMID: 20136757 BACKGROUND

MeSH Terms

Conditions

Primary Dysautonomias

Condition Hierarchy (Ancestors)

Autonomic Nervous System Diseases; Nervous System Diseases

Study Officials

• J. Derek Kingsley, PhD

  Kent State University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

J. Derek Kingsley, PhD

CONTACT

330-672-0222; jkingsle@kent.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 10, 2017
• First Posted: July 21, 2017
• Study Start: June 14, 2017
• Primary Completion: June 13, 2018
• Study Completion: June 13, 2018
• Last Updated: July 24, 2017

Record last verified: 2017-07

Locations

US (1)