The Natural History of Chronic Pancreatitis

NCT03324698 | Active Not Recruiting

• 1 other identifier: Changhai-171024
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic pancreatitis (CP) is a disease characterized by inflammation and their replacement by fibrotic tissue. The destruction of pancreatic function and structure are the main complications. This retrospective-prospective, multicenter, cohort study was conducted. This study aimed to observe the natural history of CP in China, analyse the risk factors for CP complications, and establish individual predictions.

Conditions

Chronic Pancreatitis; Complication; Risk Factors

Outcome Measures

Primary Outcomes (5)

• Pancreatic cancer

  Pancreatic cancer developed in chronic pancreatitis patients

  Dec 31, 2017

• Diabetes mellitus

  Endocrine insufficiency developed in chronic pancreatitis patients

  Dec 31, 2017

• Steatorrhea

  Exocrine insufficiency developed in chronic pancreatitis patients

  Dec 31, 2017

• Pancreatic pseudocyst

  Pancreatic pseudocyst developed in chronic pancreatitis patients

  Dec 31, 2017

• Common bile duct stricture

  Common bile duct stricture developed in chronic pancreatitis patients

  Dec 31, 2017

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Chronic pancreatitis patients in China

You may qualify if:

• Patients diagnosed with chronic pancreatitis according to Asia-Pacific consensus

You may not qualify if:

• Pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis
• Groove pancreatitis
• Autoimmune pancreatitis

Sponsors & Collaborators

• Changhai Hospital: lead
• Shenzhen People's Hospital: collaborator
• Zhongda Hospital: collaborator
• Yangzhou University: collaborator
• The First People's Hospital of Hefei: collaborator
• The Affiliated Hospital of Qingdao University: collaborator
• Jinling Hospital, China: collaborator
• Zaozhuang Central Hospital of Shandong Health Group: collaborator
• The Fifth Medical Center of the PLA General Hospital: collaborator
• The Third People's Hospital of Chengdu: collaborator
• Ruijin Hospital: collaborator
• 900th Hospital of PLA Joint Logistic Support Force: collaborator
• Air Force Medical Center of PLA: collaborator
• The Fifth Medical Center of Chinese People's Liberation Army General Hospital: collaborator
• The Affiliated Hospital of Technical University of Munich: collaborator

Study Sites (1)

Changhai Hospital, Second Military Medical University

Shanghai, 200433, China

Location

Related Publications (4)

• Li BR, Pan J, Du TT, Liao Z, Ye B, Zou WB, Chen H, Ji JT, Zheng ZH, Wang D, Lin JH, Ning SB, Hu LH, Li ZS. Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients. Sci Rep. 2016 Feb 15;6:21381. doi: 10.1038/srep21381.

  PMID: 26877248 BACKGROUND

• Hao L, Pan J, Wang D, Bi YW, Ji JT, Xin L, Liao Z, Du TT, Lin JH, Zhang D, Zeng XP, Ye B, Zou WB, Chen H, Xie T, Li BR, Zheng ZH, Hu LH, Li ZS. Risk factors and nomogram for pancreatic pseudocysts in chronic pancreatitis: A cohort of 1998 patients. J Gastroenterol Hepatol. 2017 Jul;32(7):1403-1411. doi: 10.1111/jgh.13748.

  PMID: 28127800 BACKGROUND

• Hao L, Zeng XP, Xin L, Wang D, Pan J, Bi YW, Ji JT, Du TT, Lin JH, Zhang D, Ye B, Zou WB, Chen H, Xie T, Li BR, Zheng ZH, Wang T, Guo HL, Liao Z, Li ZS, Hu LH. Incidence of and risk factors for pancreatic cancer in chronic pancreatitis: A cohort of 1656 patients. Dig Liver Dis. 2017 Nov;49(11):1249-1256. doi: 10.1016/j.dld.2017.07.001. Epub 2017 Jul 15.

  PMID: 28756974 BACKGROUND

• Hao L, Bi YW, Zhang D, Zeng XP, Xin L, Pan J, Wang D, Ji JT, Du TT, Lin JH, Ye B, Zou WB, Chen H, Xie T, Li BR, Zheng ZH, Wang T, Guo HL, Liao Z, Li ZS, Hu LH. Risk Factors and Nomogram for Common Bile Duct Stricture in Chronic Pancreatitis: A Cohort of 2153 Patients. J Clin Gastroenterol. 2019 Mar;53(3):e91-e100. doi: 10.1097/MCG.0000000000000930.

  PMID: 28961573 BACKGROUND

MeSH Terms

Conditions

Pancreatitis, Chronic

Condition Hierarchy (Ancestors)

Pancreatitis; Pancreatic Diseases; Digestive System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Gastroenterology Dept.

Study Record Dates

• First Submitted: October 25, 2017
• First Posted: October 30, 2017
• Study Start: January 1, 2000
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): January 31, 2027
• Last Updated: July 22, 2026

Record last verified: 2026-07

Locations

CN (1)