Exercise Inhibit Innate Immune Response and Ameliorate Chronic Pancreatitis

NCT06534138 | Completed

• 1 other identifier: Exercise
• Study Type: observational
• Target: 121
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the effects of different physical exercise on disease progression in patients with chronic pancreatitis. The main question it aims to answer is: Can physical exercise alleviate the disease progression of chronic pancreatitis? Currently, the investigators have followed up with participants through a telephone questionnaire for six months to investigate whether the participants have engaged in physical exercise and to assess the disease progression of chronic pancreatitis.

Conditions

Chronic Pancreatitis

Outcome Measures

Primary Outcomes (1)

• Physical Exercise Can Alleviate the Disease Progression of Chronic Pancreatitis.

  The investigators collected data on patients' exercise time and modalities through telephone questionnaires. The impact of exercise on patients with chronic pancreatitis was determined by assessing VAS scores.

  Six months

Study Arms (3)

Non-Chronic Pancreatitis (Non-CP)

Patients diagnosed without chronic pancreatitis based on imaging results were categorized into the Non-CP group.

Chronic Pancreatitis-non-exercise (CP-non-exercise)

Patients diagnosed with chronic pancreatitis based on imaging results, while simultaneously not engaging in physical exercise, were categorized into the CP-non-exercise group.

Chronic Pancreatitis-exercise (CP-exercise)

Patients diagnosed with chronic pancreatitis based on imaging results, while concurrently adhering to physical exercise, were categorized into the CP-exercise group.

Behavioral: Physical exercise

Interventions

Physical exercise BEHAVIORAL

The CP-exercise group was categorized based on patients' self-reported daily exercise time into four levels: 15 minutes/day, 30 minutes/day, 45 minutes/day, and ≥60 minutes/day. Additionally, resistance exercise and endurance exercise were distinguished based on patients' self-reported exercise modalities, including swimming, jogging, brisk walking, practicing Tai Chi, and dumbbell training.

Chronic Pancreatitis-exercise (CP-exercise)

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The 105 patients with CP were categorized into the sedentary group (CP-Sed, n = 54) and exercise group (CP-Ex, n = 51) based on self-reported exercise time per day during the six-month follow-up post the diagnosis of CP. Physical exercise time was recorded at four levels: 15 min/d, 30 min/d, 45 min/d, and 60 min/d or more.

You may qualify if:

• Clinical diagnosis of chronic pancreatitis
• Must be adhere to the guidelines of the American Gastroenterological Association

You may not qualify if:

• Autoimmune pancreatitis
• Pancreatic cancer diagnosed within 2 years after the onset of CP
• Use of drugs or toxins, or presence of viral infections

Sponsors & Collaborators

• Changhai Hospital: lead

Study Sites (1)

Changhai Hospital

Shanghai, Shanghai Municipality, 200433, China

Location

MeSH Terms

Conditions

Pancreatitis, Chronic

Interventions

Exercise

Condition Hierarchy (Ancestors)

Pancreatitis; Pancreatic Diseases; Digestive System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 25, 2024
• First Posted: August 2, 2024
• Study Start: May 18, 2023
• Primary Completion: March 24, 2024
• Study Completion: March 24, 2024
• Last Updated: August 2, 2024

Record last verified: 2024-07

Locations

CN (1)