Intravitreous CytokinE Level in pAtient With retiNal Detachment

NCT03318588 | Completed

• 1 other identifier: 2017-A02195-48
• Study Type: observational
• Target: 74
• Locations: 1 country
• Sites: 1

Brief Summary

Photoreceptor apoptosis is the basis for permanent visual loss in a number of retinal disorders including age-related macular degeneration (AMD) and retinal detachment (RD). Thus, despite tremendous advances in vitreoretinal surgery and management of rhegmatogenous RD leading to a primary reattachment rate over 95%, some patients show poor visual recovery because of photoreceptor apoptosis. Physiologically, microglial cells (resident macrophages) are present only in the inner retina. The subretinal space, located between the retinal pigment epithelium (RPE) and the photoreceptor outer segments (POS), is devoid of all mononuclear phagocytes and form a zone of immune privilege. In AMD, several studies showed a strong association between subretinal mononuclear phagocytes infiltration and advanced forms of AMD. Experimental work in mice suggest that this infiltration plays an important role in the pathogenesis of this condition by producing inflammatory cytokines. RD-induced photoreceptor apoptosis might result from similar mechanisms. The aim of this study is to determine the cytokine profile in vitreous samples from patients with RD and to compare it with those from control patients with macular hole.

Conditions

Retinal Detachment

Keywords

Retinal detachment; Photoreceptor apoptosis; Cytokine

Outcome Measures

Primary Outcomes (1)

• Intravitreous cytokine levels

  up to one month after surgery

Study Arms (2)

Case

Patients undergoing vitrectomy for primary retinal detachment

Procedure: Vitrectomy

Control

Patients undergoing vitrectomy for idiopathic macular hole

Procedure: Vitrectomy

Interventions

Vitrectomy PROCEDURE

Pars plana vitrectomy

Case; Control

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients from the department of Ophthalmology (Nancy University Hospital)

You may qualify if:

• Patients with primary retinal detachment requiring vitrectomy
• Patients with idiopathic macular hole requiring vitrectomy

You may not qualify if:

• History of retinal detachment or intraocular inflammatory diseases

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

Brabois Hospital

Vandœuvre-lès-Nancy, 54500, France

Location

Related Publications (1)

• Conart JB, Blot G, Augustin S, Millet-Puel G, Roubeix C, Beguier F, Charles-Messance H, Touhami S, Sahel JA, Berrod JP, Leveillard T, Guillonneau X, Delarasse C, Sennlaub F. Insulin inhibits inflammation-induced cone death in retinal detachment. J Neuroinflammation. 2020 Nov 26;17(1):358. doi: 10.1186/s12974-020-02039-1.

  PMID: 33243251 DERIVED

MeSH Terms

Conditions

Retinal Detachment

Interventions

Vitrectomy

Condition Hierarchy (Ancestors)

Retinal Diseases; Eye Diseases

Intervention Hierarchy (Ancestors)

Ophthalmologic Surgical Procedures; Surgical Procedures, Operative

Study Officials

• Jean-Baptiste CONART, MD

  Brabois Hospital, Department of Ophthalmology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: October 19, 2017
• First Posted: October 24, 2017
• Study Start: November 15, 2017
• Primary Completion: June 28, 2018
• Study Completion: October 11, 2018
• Last Updated: July 20, 2022

Record last verified: 2022-07

Locations

FR (1)