Remediation of Visual Perceptual Impairments in People With Schizophrenia
VRiS
Visual Remediation in Schizophrenia
2 other identifiers
interventional
79
1 country
2
Brief Summary
The purpose of this study is to evaluate the effectiveness of a visual remediation intervention for people with schizophrenia. The intervention targets two visual functions that much research has shown are impaired in many people with the disorder, namely contrast sensitivity and perceptual organization. The first phase of the study will test the effects of interventions targeting each of these processes, as well as the effects of a combined package. A control condition of higher-level cognitive remediation is included as a fourth condition. The second phase of the study will evaluate the effectiveness of the most effective intervention from the first phase, but in a new and larger sample of individuals. Outcome measures include multiple aspects of visual functioning, as well as visual cognition and overall community functioning.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable schizophrenia
Started Jun 2018
Longer than P75 for not_applicable schizophrenia
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 4, 2017
CompletedFirst Posted
Study publicly available on registry
October 19, 2017
CompletedStudy Start
First participant enrolled
June 1, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
May 31, 2025
CompletedSeptember 5, 2025
September 1, 2025
6.8 years
October 4, 2017
September 3, 2025
Conditions
Outcome Measures
Primary Outcomes (3)
Contrast sensitivity - behavioral
Peak contrast, as measures by a behavioral (psychophysical) measure of contrast sensitivity.
Years 1-5
Contrast sensitivity - electrophysiological
Steady state visual evoked potential (ssVEP) amplitudes recorded during the contrast sensitivity task.
Years 1-5
Contour integration
Total score on the Jittered-Orientation Visual Integration Task, or JOVI), a psychophysical measure of perceptual organization.
Years 1-5
Secondary Outcomes (4)
Reading speed
Years 3-5
Emotion recognition
Years 3-5
Cognition
Years 3-5
Community functioning
Years 3-5
Study Arms (4)
Contrast sensitivity
EXPERIMENTALUltimEyes
Perceptual organization
EXPERIMENTALContour Integration Training
Contrast sensitivity + Perceptual org.
EXPERIMENTALUltimEyes + Contour Integration Training
Cognitive remediation
ACTIVE COMPARATORMyBrainSolutions
Interventions
A computer program developed to improve contrast sensitivity and visual acuity.
A computerized program to improve contour integration (a form of perceptual organization).
The combination of UltimEyes and Contour Integration Training
A computer program consisting of exercises to improve cognition (attention, memory, planning) and to facilitate goal setting.
Eligibility Criteria
You may qualify if:
- SCID-5 diagnosis of schizophrenia;
- years old;
- speaks English;
- able to complete the MATRICS Consensus Cognitive Battery (MCCB) at the baseline assessment (for R33);
- a raw score of 37 or greater on the Wide Range Achievement Test, Reading subtest (WRAT-3), to establish a minimum reading level (6th grade) and to estimate premorbid IQ; and
- clinically stable as indicated by no antipsychotic medication changes in the last month or if on depot, no change in the past 2 months.
You may not qualify if:
- history of intellectual disability, or developmental or neurological disorder;
- history of brain trauma associated with loss of consciousness for \> 10 minutes or behavioral sequelae;
- alcohol or substance use disorder within the last 6 months; and
- history of eye disease (e.g., glaucoma, retinopathy).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Rochesterlead
- New York Universitycollaborator
- Weill Medical College of Cornell Universitycollaborator
- National Institute of Mental Health (NIMH)collaborator
Study Sites (2)
University of Rochester Medical Center - Strong Ties Community Support Clinic
Rochester, New York, 14623, United States
New York Presbyterian Hospital
White Plains, New York, 10605, United States
Related Publications (2)
Silverstein SM, Seitz AR, Ahmed AO, Thompson JL, Zemon V, Gara M, Butler PD. Development and Evaluation of a Visual Remediation Intervention for People with Schizophrenia. J Psychiatr Brain Sci. 2020;5:e200017. doi: 10.20900/jpbs.20200017. Epub 2020 Jul 20.
PMID: 32789191BACKGROUNDButler PD, Thompson JL, Seitz AR, Deveau J, Silverstein SM. Visual perceptual remediation for individuals with schizophrenia: Rationale, method, and three case studies. Psychiatr Rehabil J. 2017 Mar;40(1):43-52. doi: 10.1037/prj0000212. Epub 2016 Aug 22.
PMID: 27547852RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Steven M Silverstein, Ph.D.
University of Rochester
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- CARE PROVIDER, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 4, 2017
First Posted
October 19, 2017
Study Start
June 1, 2018
Primary Completion
March 31, 2025
Study Completion
May 31, 2025
Last Updated
September 5, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will not share