Vitamin D Deficiency of Couples and Infertility
Prospective Cohort Study About Vitamin D Deficiency of Couples and Infertility
1 other identifier
observational
1,500
0 countries
N/A
Brief Summary
Between March 2016 and March 2017, we performed a large retrospective, non-interventional, single-center cohort study and measured 25(OH)D3 plasma levels prior to ovarian stimulation in couples who underwent IVF/ICSI.And we analysed the correlation of vitamin D status and reproductive capacity .
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2016
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2017
CompletedFirst Submitted
Initial submission to the registry
October 8, 2017
CompletedFirst Posted
Study publicly available on registry
October 10, 2017
CompletedOctober 10, 2017
October 1, 2017
1 year
October 8, 2017
October 9, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
fertilization rate
Normal fertilization rate was defined as the presence of two pronuclei (2PN) at the time of fertilization assessment, 16-19 h after ICSI or conventional insemination. The percentage of top quality embryos was defined as the percentage of top quality embryos among the total number of 2PN embryos. Blastocyst forming rate was calculated as number of formed blastocysts devided by number of cultured blastocysts.
the time of fertilization assessment, 16-19 hours after ICSI or conventional insemination
Study Arms (3)
Vitamin D deficiency
The level of vitamin D is below 20ng/ml.
Vitamin D insufficient
The level of vitamin D is between 20ng/ml and 30ng/ml.
Vitamin D sufficient
The level of vitamin D is above 30ng/ml.
Interventions
Eligibility Criteria
non-interventional, single-center cohort study and measured 25(OH) D plasma levels prior to ovarian stimulation in couples who underwent IVF/ICSI.
You may qualify if:
- couples who underwent IVF/ICSI.
You may not qualify if:
- sperm or egg donation, PGD or PGS,TESA or PESA, ovum frozen ,no oocyte for fertilization.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Tongji Hospitallead
Related Publications (1)
Jiang L, Yang J, Song J, Hu Y, Qian K. Normal fertilisation rates and serum 25-OHD levels among couples undergoing in-vitro fertilisation: a prospective cohort study. BMC Pregnancy Childbirth. 2020 Jun 5;20(1):346. doi: 10.1186/s12884-020-02959-z.
PMID: 32503520DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Kun Qian, Doctor
Tongji Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD
Study Record Dates
First Submitted
October 8, 2017
First Posted
October 10, 2017
Study Start
March 1, 2016
Primary Completion
March 1, 2017
Study Completion
June 1, 2017
Last Updated
October 10, 2017
Record last verified: 2017-10