Development of Eye-tracking Based Markers for Autism in Young Children

NCT03286621 | Completed

• 1 other identifier: UESCT_neuSCAN_41
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The main aim of the present study is to examine eye-tracking based markers for social processing deficits in children with autism spectrum disorder (ASD). To this end a battery of five eye-tracking paradigms will be administered to young children with ASD and typically developing children. To additionally evaluate the specificity of the eye-tracking markers a group of children with disorders of delayed development other than ASD will be included.

Conditions

Autism Spectrum Disorder

Keywords

eye tracking; visual preference

Outcome Measures

Primary Outcomes (2)

• Global eye-gaze characteristics

  Global eye-gaze patterns between the three groups will be compared to determine ASD specific alterations

  Single assessment, total duration 20 minutes

• Feature-specific eye-gaze characteristics

  Localized feature-specific eye-gaze patterns will be compared between the three groups to determine ASD specific alterations

  Single assessment, total duration 20 minutes

Secondary Outcomes (2)

• Global eye-gaze characteristics and associations with symptom severity

  Single assessment, total duration 20 minutes

• Feature-specific eye-gaze characteristics and associations with symptom severity

  Single assessment, total duration 20 minutes

Study Arms (3)

Children with Autism Spectrum Disorder

Children with an Autism Spectrum Disorder according to DSM-5 criteria

Other: Administration of five eye-tracking paradigms

Typically Developing Children

Typically developing children

Other: Administration of five eye-tracking paradigms

Children with Delayed Development Disorders

Children with Delayed Developmental Disorders other than ASD

Other: Administration of five eye-tracking paradigms

Interventions

Administration of five eye-tracking paradigms OTHER

All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism.

Children with Autism Spectrum Disorder; Children with Delayed Development Disorders; Typically Developing Children

Eligibility Criteria

• Age: 12 Months - 10 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Children with ASD according to DSM-5 criteria will be compared with typically developing children and a group of children with unspecific delayed development disorders.

You may not qualify if:

• visual, auditory or motor impairments
• use of medication
• written informed consent from parents / caregiver
• age: 1-10 years
• \- diagnosis of Autism Spectrum Disorder according to DSM-5
• no symptoms of developmental disorders
• no current or history of psychological disorder
• \- disorder of delayed development other than ASD

Sponsors & Collaborators

• University of Electronic Science and Technology of China: lead

Study Sites (1)

School of Life Science and Technology, University of Electronic Science and Technology of China

Chengdu, Sichuan, 610054, China

Location

Related Publications (1)

• Kou J, Le J, Fu M, Lan C, Chen Z, Li Q, Zhao W, Xu L, Becker B, Kendrick KM. Comparison of three different eye-tracking tasks for distinguishing autistic from typically developing children and autistic symptom severity. Autism Res. 2019 Oct;12(10):1529-1540. doi: 10.1002/aur.2174. Epub 2019 Aug 1.

  PMID: 31369217 DERIVED

MeSH Terms

Conditions

Autism Spectrum Disorder

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Juan Kou, MSc

  University of Electronic Science and Technology of China

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 14, 2017
• First Posted: September 18, 2017
• Study Start: September 9, 2017
• Primary Completion: February 28, 2018
• Study Completion: February 28, 2018
• Last Updated: October 29, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)