NCT03285880

Brief Summary

The specific objective of the proposed research is to examine whether naps contribute to immediate and delayed benefits on multiple forms of learning in young children (3-5 yrs). By probing recall prior to and following mid-day nap or wake intervals, the overarching hypothesis is that recent memories are actively processed (as opposed to passively protected) by a nap, conferring immediate or delayed (24-hrs) benefits on declarative (Aim 1), procedural (Aim 2), and emotional (Aim 3) memories. In two conditions, children will either be nap-promoted or wake-promoted midday. Subsequently, performance will be reassessed that day as well as the following day.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
361

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 2017

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2017

Completed
13 days until next milestone

First Submitted

Initial submission to the registry

September 14, 2017

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 18, 2017

Completed
4.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2022

Completed
Last Updated

December 5, 2022

Status Verified

November 1, 2022

Enrollment Period

4.8 years

First QC Date

September 14, 2017

Last Update Submit

November 30, 2022

Conditions

Sleep

Outcome Measures

Primary Outcomes (1)

  • Change in memory accuracy

    Accuracy on the memory task following the nap compared to before the nap relative to the same memory change measured over an interval spent awake

    4-5 hours

Study Arms (3)

Declarative memory

EXPERIMENTAL

Napping v. wake effect on a declarative memory task (storybook)

Behavioral: Napping

Procedural memory

EXPERIMENTAL

Napping v. wake effect on a procedural memory task (motor sequence learning or mirror tracing)

Behavioral: Napping

Emotional memory

EXPERIMENTAL

Napping v. wake effect on an emotional memory task (emotional faces or storybook)

Behavioral: Napping

Interventions

NappingBEHAVIORAL

Children nap during the nap opportunity

Declarative memoryEmotional memoryProcedural memory

Eligibility Criteria

Age33 Months - 60 Months
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • be enrolled in a preschool testing site or available to come into the lab

You may not qualify if:

  • Diagnosis of any sleep disorder(other than mild parasomnia) past or present
  • Current use of psychotropic or sleep-altering medications
  • traveling beyond 1 time zone within 1 month of testing
  • fever or symptoms of respiratory illness at the time of testing
  • physical handicap which interferes with assessments (vision, hearing impairment)
  • diagnosed developmental disability

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Massachusetts

Amherst, Massachusetts, 01003, United States

Location

Related Publications (3)

  • Kurdziel L, Duclos K, Spencer RM. Sleep spindles in midday naps enhance learning in preschool children. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17267-72. doi: 10.1073/pnas.1306418110. Epub 2013 Sep 23.

    PMID: 24062429BACKGROUND

  • Desrochers PC, Kurdziel LB, Spencer RM. Delayed benefit of naps on motor learning in preschool children. Exp Brain Res. 2016 Mar;234(3):763-72. doi: 10.1007/s00221-015-4506-3. Epub 2015 Dec 8.

    PMID: 26645305BACKGROUND

  • St Laurent CW, Rasmussen CL, Holmes JF, Cremone-Caira A, Kurdziel LBF, Desrochers PC, Spencer RMC. Associations of activity, sedentary, and sleep behaviors with cognitive and social-emotional health in early childhood. J Act Sedentary Sleep Behav. 2023;2(1):7. doi: 10.1186/s44167-023-00016-6. Epub 2023 Apr 3.

    PMID: 38798902DERIVED

Related Links

Study Officials

  • Rebecca M Spencer, PhD

    University of Massachusetts, Amherst

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Masking Details
Within-subject; participants/experimenters are aware of conditions
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Model Details: Within subject comparison of nap and wake conditions
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Psychological and Brain Sciences

Study Record Dates

First Submitted

September 14, 2017

First Posted

September 18, 2017

Study Start

September 1, 2017

Primary Completion

June 30, 2022

Study Completion

June 30, 2022

Last Updated

December 5, 2022

Record last verified: 2022-11

Data Sharing

IPD Sharing
Will not share

Locations

US(1)