Expression of G-protein Coupled Receptor 120 Receptor in Adipose Tissue of German Diabetes Center Cohort Subjects

NCT03285750 | Completed

• 1 other identifier: GPR120 study
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

G-protein coupled receptor 120 (GPR120) is a G-protein-coupled receptor whose endogenous ligands have been identified as long-chain fatty acids. Recently, it has been shown that GPR120 expression in human adipose tissue is higher in obese than in lean individuals. Interestingly, a GPR120 deficient mouse model presents an unfavorable phenotype when fed a high-fat diet with obesity, glucose intolerance and fatty liver, characteristics also found in type 2 diabetes (T2D). Moreover, in obese subjects, a single nucleotide polymorphism (R270H) has been identified that inhibits GPR120 signaling activity. The investigators now want to investigate if GPR120 expression in adipose tissue may be altered in patients with T2D compared to non-diabetic subjects and might contribute to diabetes-associated metabolic changes. Additionally, the investigators want to assess the frequency of the R270H mutant in T2D.

Conditions

Type 2 Diabetes

Keywords

GPR120; Adipose tissue; Type 2 diabetes

Outcome Measures

Primary Outcomes (1)

• GPR120 expression in adipose tissue

  GPR expression is measured in adipose tissue of recently diagnosed type 2 diabetic patients and age- and BMI-matched normoglycemic controls

  Expression measured at baseline (day 1)

Study Arms (2)

Diabetic group

Patients with recently diagnosed type 2 diabetes

Controls

Age- and BMI-matched normoglycemic subjects

Eligibility Criteria

• Age: 20 Years - 69 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with recently diagnosed type 2 diabetes (up to one year from diagnosis) and age- and weight-matched normoglycemic controls

You may qualify if:

• Type 2 diabetes mellitus / normoglycemia
• BMI \< 27,5 or \> 30 kg/m2
• Age 20 - 69 years

You may not qualify if:

• severe chronic diseases
• anemia
• medication altering fatty acid metabolism

Sponsors & Collaborators

• German Diabetes Center: lead

Study Sites (1)

German Diabetes Center

Düsseldorf, North Rhine-Westphalia, 40225, Germany

Location

Biospecimen

Retention: SAMPLES WITH DNA

SNP Genotyping of GPR120

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Michael Roden, Prof., MD

  German Diabetes Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 13, 2013
• First Posted: September 18, 2017
• Study Start: August 1, 2013
• Primary Completion: September 1, 2017
• Study Completion: September 1, 2017
• Last Updated: June 15, 2023

Record last verified: 2023-06

Locations

DE (1)