NCT03285750|Completed
Expression of G-protein Coupled Receptor 120 Receptor in Adipose Tissue of German Diabetes Center Cohort Subjects
GPR120
Expression of GPR120 Receptor in Adipose Tissue of Type 2 Diabetic Subjects
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GPR120
Expression of GPR120 Receptor in Adipose Tissue of Type 2 Diabetic Subjects
Sponsor study identifier
observational
50
1 country
1
Study Start
August 2013
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2017
Actual (reported)Study Completion
September 2017
Actual (reported)G-protein coupled receptor 120 (GPR120) is a G-protein-coupled receptor whose endogenous ligands have been identified as long-chain fatty acids. Recently, it has been shown that GPR120 expression in human adipose tissue is higher in obese than in lean individuals. Interestingly, a GPR120 deficient mouse model presents an unfavorable phenotype when fed a high-fat diet with obesity, glucose intolerance and fatty liver, characteristics also found in type 2 diabetes (T2D). Moreover, in obese subjects, a single nucleotide polymorphism (R270H) has been identified that inhibits GPR120 signaling activity. The investigators now want to investigate if GPR120 expression in adipose tissue may be altered in patients with T2D compared to non-diabetic subjects and might contribute to diabetes-associated metabolic changes. Additionally, the investigators want to assess the frequency of the R270H mutant in T2D.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2017
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 2013
Date type not reportedThis date has not been verified as actual or estimated.
August 13, 2013
Actual (reported)September 2017
Actual (reported)September 2017
Actual (reported)September 18, 2017
Actual (reported)GPR120 expression in adipose tissue
GPR expression is measured in adipose tissue of recently diagnosed type 2 diabetic patients and age- and BMI-matched normoglycemic controls
Expression measured at baseline (day 1)
Patients with recently diagnosed type 2 diabetes
Age- and BMI-matched normoglycemic subjects
Patients with recently diagnosed type 2 diabetes (up to one year from diagnosis) and age- and weight-matched normoglycemic controls
German Diabetes Center
Düsseldorf, North Rhine-Westphalia, 40225, Germany
SNP Genotyping of GPR120
Michael Roden, Prof., MD
German Diabetes Center
50 participants (actual enrollment reported by the registry).
First Submitted
August 13, 2013
First Posted
September 18, 2017
Study Start
August 2013
Date type not reportedThis date has not been verified as actual or estimated.
Evaluation of a Diabetes Self-Management Education Program for Non-Intensified Insulin Therapy in Type 2 Diabetes
Contact the study team to confirm eligibility.
Primary Completion
September 2017
Actual (reported)Study Completion
September 2017
Actual (reported)Last Updated
June 15, 2023
Record last verified: 2023-06
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Source: ClinicalTrials.gov.
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