Priming Exercise in Type 1 Diabetes

NCT03285386 | Completed

• 1 other identifier: LiverpoolHopeUni
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

Critical power is an important threshold in exercise physiology, and is an important determinant of the ability to tolerate high-intensity exercise. The ability to tolerate such exercise is drastically impaired in certain chronic conditions, such as type 1 diabetes. Whilst the most important physiological factors that determine critical power have yet to be determined, previous work from our laboratory suggests that it is related to the speed of oxygen uptake at the onset of exercise. This study will look to utilise "priming" exercise as an intervention to improve the speed of these oxygen uptake "kinetics", and thus critical power and exercise tolerance in individuals with type 1 diabetes. We hypothesize that oxygen uptake kinetics will be faster and critical power will be higher when exercise is performed with compared to without a prior bout of high-intensity priming exercise in a population of individuals with type 1 diabetes.

Conditions

Type 1 Diabetes Mellitus

Outcome Measures

Primary Outcomes (3)

• Critical power

  The power asymptote of the hyperbolic relationship between power and the tolerable duration of exercise.

  3-9 weeks

• Phase II time constant of pulmonary oxygen uptake kinetics

  Time taken for oxygen uptake to attain 63% of its asymptotic amplitude.

  3-9 weeks

• Time constant for muscle deoxygenation kinetics (assessed by near-infrared spectroscopy)

  Time taken for muscle deoxyhaemoglobin to attain 63% of its asymptotic amplitude.

  3-9 weeks

Secondary Outcomes (2)

• W'

  3-9 weeks

• Time constant for heart rate kinetics

  3-9 weeks

Study Arms (2)

Priming Exercise

EXPERIMENTAL

Participants will perform constant power output tests at four separate, fixed intensities to exhaustion on a cycle ergometer on separate days. These exhaustive, constant power tests will be preceded by 3 minutes of light cycling, 6 minutes of high intensity cycling, 7 minutes of rest and 3 minutes of light cycling.

Behavioral: Priming exercise

Control

ACTIVE COMPARATOR

Participants will perform constant power output tests at four separate, fixed intensities to exhaustion on a cycle ergometer on separate days. These exhaustive, constant power tests will be preceded by 3 minutes of light cycling only.

Behavioral: Control Exercise

Interventions

Priming exercise BEHAVIORAL

All participants will perform a bout of high-intensity "priming" exercise for 6 minutes, 10 minutes prior to undertaking an exhaustive exercise test on four separate occasions.

Priming Exercise

Control Exercise BEHAVIORAL

All participants will perform 3 minutes of baseline cycling prior to undertaking an exhaustive exercise test on four separate occasions.

Control

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Suffering from Type 1 diabetes with a diagnosed disease duration of 2 - 20 years and no comorbidities.

You may not qualify if:

• History of stroke, congestive heart failure, hypertension, or cardiopulmonary disease.
• Current smoking or have been smoking within the last 12 months Symptomatic autonomic or distal neuropathy HbA1c \> 64 mmol/mol Hypoglycaemia unawareness in the last 6 months Taking any medications other than insulin.

Sponsors & Collaborators

• Liverpool Hope University: lead

Study Sites (1)

Liverpool Hope University

Liverpool, Merseyside, L169JD, United Kingdom

Location

Related Publications (5)

• Goulding RP, Roche DM, Marwood S. Prior exercise speeds pulmonary oxygen uptake kinetics and increases critical power during supine but not upright cycling. Exp Physiol. 2017 Sep 1;102(9):1158-1176. doi: 10.1113/EP086304. Epub 2017 Jul 26.

  PMID: 28627041 BACKGROUND

• Behnke BJ, Kindig CA, McDonough P, Poole DC, Sexton WL. Dynamics of microvascular oxygen pressure during rest-contraction transition in skeletal muscle of diabetic rats. Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H926-32. doi: 10.1152/ajpheart.00059.2002.

  PMID: 12181120 BACKGROUND

• Sexton WL, Poole DC, Mathieu-Costello O. Microcirculatory structure-function relationships in skeletal muscle of diabetic rats. Am J Physiol. 1994 Apr;266(4 Pt 2):H1502-11. doi: 10.1152/ajpheart.1994.266.4.H1502.

  PMID: 8184927 BACKGROUND

• Kindig CA, Sexton WL, Fedde MR, Poole DC. Skeletal muscle microcirculatory structure and hemodynamics in diabetes. Respir Physiol. 1998 Feb;111(2):163-75. doi: 10.1016/s0034-5687(97)00122-9.

  PMID: 9574868 BACKGROUND

• Burnley M, Davison G, Baker JR. Effects of priming exercise on VO2 kinetics and the power-duration relationship. Med Sci Sports Exerc. 2011 Nov;43(11):2171-9. doi: 10.1249/MSS.0b013e31821ff26d.

  PMID: 21552161 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus, Type 1

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Richie P Goulding

  Liverpool Hope University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants will serve as their own controls. Participants will alternate between "primed" (experimental condition) and "non-primed" (control condition) in their visits.

Study Record Dates

• First Submitted: September 14, 2017
• First Posted: September 18, 2017
• Study Start: January 1, 2018
• Primary Completion: December 1, 2018
• Study Completion: December 1, 2018
• Last Updated: March 1, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)