Thermal Imaging in Liver Disease.

NCT03279419 | Completed

• 1 other identifier: IRAS ID 189169
• Study Type: observational
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

This is a feasibility study, to assess if thermal imaging and/or near infrared imaging will be useful in identifying changes in the peripheral circulation in patients with different stages of liver disease. The aim of this study is to use new and advanced thermal imaging techniques to identify changes in the peripheral circulation and hand temperature in patients with liver disease. These changes could be used as a non-invasive marker of the severity and progression of liver disease. Thermal imaging will also be used to assess the changes in the peripheral vasculature with the use of terlipressin, a drug used as treatment for specific complications of liver disease. Patients with acute or chronic liver disease from any aetiology will be recruited, along with patients without liver disease as healthy controls. Patients with disease or on drugs known to affect the peripheral vasculature will be excluded. All studies will be performed in a ward setting in the Royal Infirmary of Edinburgh. The subjects will be required for up to three sessions, each lasting 30 minutes. The session will involve static thermal images being taken, and video images of the hands warming up after being cooled for 30 seconds in water at a temperature of 7 degrees Celsius. If the patient is receiving terlipressin therapy, static images will be taken before, during and after terlipressin therapy.

Conditions

Liver Diseases

Outcome Measures

Primary Outcomes (1)

• Changes in peripheral vasculature as assessed by thermal imaging

  2 years

Secondary Outcomes (1)

• Changes in peripheral vasculature in response to terlipressin therapy.

  2 years

Study Arms (2)

Liver disease

15 patients with acute or chronic liver disease of any aetiology. Serial static images to be taken at up to 3 time points using thermal imaging camera. Video images using thermal camera will be used to capture warming of one hand after cooling. Patient may or may not be receiving terlipressin therapy.

Diagnostic Test: Thermal imaging

Normal

15 patients without liver disease, and without any other disease or drug known to affect the peripheral circulation. Serial static images to be taken at up to 3 time points using thermal imaging camera. Video images using thermal camera will be used to capture warming of one hand after cooling.

Diagnostic Test: Thermal imaging

Interventions

Thermal imaging DIAGNOSTIC_TEST

Use of thermal imaging camera to capture images of peripheral vasculature (hands).

Liver disease; Normal

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 18-70 with acute or chronic liver disease

You may qualify if:

• diagnosis of chronic liver disease (any stage)
• diagnosis of acute liver disease (any aetiology)

You may not qualify if:

• on drugs known to affect peripheral circulation
• conditions known to affect peripheral circulation e.g. Raynauds

Sponsors & Collaborators

• University of Edinburgh: lead

Study Sites (1)

Univerity of Edinburgh and NHS Lothian

Edinburgh, United Kingdom

Location

MeSH Terms

Conditions

Liver Diseases

Condition Hierarchy (Ancestors)

Digestive System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 8, 2017
• First Posted: September 12, 2017
• Study Start: September 1, 2019
• Primary Completion: September 1, 2019
• Study Completion: December 1, 2019
• Last Updated: June 18, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)