An Iodine Balance Experiment

NCT03279315 | Completed

• 1 other identifier: NSFC-31340033
• Study Type: interventional
• Target: 25
• Locations: 0 countries
• Sites: N/A

Brief Summary

A 4-week study was conducted in 25 Chinese euthyroid women. Unified diets with different iodine contents (cooked with non-iodized salt or iodized salt) were provided in two different periods. The total iodine intake from diet, water and air as well as the total iodine excretion by urine, faces and respiration were monitored and determined, and a total of 300 samples were collected. The sweat iodine loss was also considered. Moreover, the regression curve model between the 24-h iodine intake and 24-h iodine excretion was also established.

Conditions

Iodine Deficiency; Nutritional Requirements

Keywords

Iodine; Balance experiment; EAR; Chinese women; Euthyroid

Outcome Measures

Primary Outcomes (4)

• Total iodine intake and total iodine excretion

  Iodine intake includes iodine from food, water and air (μg/d).

  12 days

• Total iodine excretion

  Iodine excretion includes iodine excreted by urine, feces, sweat and breath (μg/d).

  12 days

• urinary iodine concentration (UIC)

  μg/L

  At the beginning of the experiment

• Thyroid function

  FT3 (pmol/L), FT4 (pmol/L),TSH (mIU/L), TG (ng/mL), TGAb (IU/mL), TPOAb (IU/mL)

  At the beginning of the experiment

Study Arms (1)

experimental period

EXPERIMENTAL

the first period was with non-iodized salt, the second period was with iodized salt.

Dietary Supplement: iodized table salt, non-iodized table salt

Interventions

iodized table salt, non-iodized table salt DIETARY_SUPPLEMENT

During the first 3 weeks, the diet was provided with non-iodized salt, while the diet with iodized salt was only offered in the last week.

experimental period

Eligibility Criteria

• Age: 19 Years - 25 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• The ones with normal thyroid function, urinary iodine concentration, agree with the experiment.

You may not qualify if:

• The ones with abnormal thyroid hormone level, urinary iodine concentration (UIC) or autoantibody-positive were excluded from the study.

Sponsors & Collaborators

• Tianjin Medical University: lead

Related Publications (1)

• Wang Y, Tian X, Song Q, Wang W, Guo X, Cui T, Pan Z, Chen Y, Chen W, Tan L, Zhang W. Application and Comparison of Different Regression Models in Iodine Balance Experiment on Women of Childbearing Age and Pregnant Women. Biol Trace Elem Res. 2024 Jun;202(6):2474-2487. doi: 10.1007/s12011-023-03867-x. Epub 2023 Oct 9.

  PMID: 37807000 DERIVED

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Participants received a diet with iodized table salt or non-iodized table salt

Study Record Dates

• First Submitted: September 7, 2017
• First Posted: September 12, 2017
• Study Start: November 20, 2014
• Primary Completion: December 19, 2014
• Study Completion: March 10, 2017
• Last Updated: September 12, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will not share