French National Observatory on Infective Endocarditis

NCT03272724 | Recruiting

• 1 other identifier: Observatoire EI
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this observatory is to provide a national database of infective endocarditis, informed by all volunteer centers, using a standardized case report forms. Such an observatory will describe the clinical profile, microbiological, therapeutic and evolving of infective endocarditis (IE); analyze the risk factors for the disease and its prognosis factors of evolution; describe management practices; evaluate and compare in the real drug treatment strategies (including antibiotics) and surgical.

Conditions

Infective Endocarditis

Outcome Measures

Primary Outcomes (11)

• history of heart disease

  status of heart valves, pre-existing heart conditions

  inclusion

• risk factors, medical history

  associated diseases

  inclusion

• origin of infection

  high risk procedures

  period of 3 months before infective endocarditis

• weight

  kg

  inclusion

• height

  cm

  inclusion

• clinical symptoms

  cardiac, peripheral and neurological symptoms

  inclusion

• biological outcomes

  blood count

  inclusion

• microbiological outcomes

  identification of infecting organisms

  inclusion

• diagnostic imaging

  description of tyhe imaging tests performed

  inclusion

• antibiotic therapy

  antibiotic treatment: type and duration

  from inclusion to recovery

• surgical procedures

  description of surgical procedures

  from inclusion to recovery

Secondary Outcomes (1)

• biologic collection (optional)

  inclusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult hospitalized patients, suspected of infective endocarditis

You may qualify if:

• Major Patient
• Supported in one of the participating centers
• The application of diagnostic classification criteria of Duke modified by Li is carried out after collection of all the data at the end of the patient's hospitalization. Only patients meeting criteria for definite or possible endocarditis will be included in the analyses.
• Registered with the French social security system

You may not qualify if:

• Refusal of the patient to participate.

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead
• Bichat Hospital: collaborator
• Centre Hospitalier Universitaire de la Guadeloupe: collaborator
• Centre Hospitalier Universitaire de Besancon: collaborator
• Hospices Civils de Lyon: collaborator
• University Hospital, Montpellier: collaborator
• Rennes University Hospital: collaborator
• Hôpital Saint André, Reims: collaborator
• Henri Mondor University Hospital: collaborator
• Polyclinique Courlancy, Reims: collaborator
• Centre Hospitalier Universitaire de Saint Etienne: collaborator
• Bicetre Hospital: collaborator
• Centre Hospitalier Universitaire, Amiens: collaborator
• Centre Hospitalier Universitaire Dijon: collaborator
• Centre Hospitalier Annecy Genevois: collaborator
• Centre Hospitalier de Roanne: collaborator
• Centre hospitalier Pierre Oudot Bourgoin-Jallieu: collaborator
• L'hôpital Nord-Ouest - Villefranche Villefranche sur Saône: collaborator
• Hôpital d'Instruction des Armées Desgenettes: collaborator
• Hôpital intercommunal Sud Léman Valserine, Saint Julien en Genevois: collaborator
• University Hospital, Grenoble: collaborator
• Centre Cardiologique du Nord: collaborator
• Centre Hospitalier Intercommunal Robert Ballanger: collaborator
• Raincy Montfermeil Hospital Group: collaborator
• Pitié-Salpêtrière Hospital: collaborator
• Hôpital Cochin: collaborator
• Hospital Avicenne: collaborator
• Beaujon Hospital: collaborator
• European Georges Pompidou Hospital: collaborator
• Hopital Foch: collaborator
• Hotel Dieu Hospital: collaborator
• Hôpital Jean Verdier: collaborator
• Hopital Lariboisière: collaborator
• Hôpital Necker-Enfants Malades: collaborator
• Fondation Hôpital Saint-Joseph: collaborator
• Saint-Louis Hospital, Paris, France: collaborator
• Tenon Hospital, Paris: collaborator
• Saint Antoine University Hospital: collaborator
• Centre hospitalier de Saint Dié des Vosges: collaborator
• Centre Hospitalier Régional Metz-Thionville: collaborator
• Hôpital d'Instruction des Armées Legouest: collaborator
• Hôpital sainte Blandine Metz: collaborator
• Hôpital-clinique Claude Bernard, Metz: collaborator
• Polyclinique Louis Pasteur Essey-les-Nancy: collaborator
• Hopital Nord Franche-Comte: collaborator
• Lons le Saunier hospital: collaborator
• Pontarlier hospital: collaborator
• Epernay hospital: collaborator
• Chalons en Champagne hospital: collaborator
• Clinique Saint Vincent Epernay: collaborator
• Hôpital Maison Blanche Reims: collaborator
• Hopital Universitaire Robert-Debre: collaborator
• Beziers Hospital: collaborator
• Louis Pasteur hospital, Bagnols sur Cèze: collaborator
• Centre hospitalier de Perpignan: collaborator
• Narbonne Hospital: collaborator
• Clinique du Millenaire: collaborator
• Centre Hospitalier Universitaire de Nīmes: collaborator
• Saint Malo hospital: collaborator
• HIA Begin, Saint Mandé: collaborator
• Centre Hospitalier d'Alès-Cévennes: collaborator
• University Hospital, Bordeaux: collaborator
• Centre hospitalier de Chambéry: collaborator
• Poitiers University Hospital: collaborator
• Centre Hospitalier Intercommunal Villeneuve Saint Georges: collaborator
• Centre Hospitalier Argenteuil: collaborator
• Hospital St. Joseph, Marseille, France: collaborator
• Centre hospitalier de Vannes: collaborator
• University Hospital, Strasbourg, France: collaborator
• Centre Hospitalier Régional d'Orléans: collaborator

Study Sites (1)

CHRU

Vandœuvre-lès-Nancy, 54511, France

RECRUITING

Related Publications (16)

• Lefevre B, Habib G, Hoen B, Selton-Suty C, Philip M, Issa N, Danneels P, De La Chapelle M, Deschanvres C, Erpelding ML, Tattevin P, Le Bot A, Villamarin M, Fernandez-Hidalgo N, Tribouilloy C, Pluquet E, Dubee V, Hannan M, Dornikova G, Durante-Mangoni E, Bertolino L, Siciliano RF, Amaral de Oliveira AM, Goulart Correia M, Gouriet F, Lamas C. Staphylococcus lugdunensis infective endocarditis: a multicentre international observational study. Infect Dis (Lond). 2025 Sep 15:1-9. doi: 10.1080/23744235.2025.2556921. Online ahead of print.

  PMID: 40952378 BACKGROUND

• Selton-Suty C, Goehringer F, Venner C, Thivilier C, Huttin O, Hoen B; membres de l'Endocarditis Team du CHU de Nancy. [Complications and prognosis of infective endocarditis]. Presse Med. 2019 May;48(5):532-538. doi: 10.1016/j.lpm.2019.04.002. Epub 2019 May 2. French.

  PMID: 31056233 BACKGROUND

• Hoen B, Elfarra M, Huttin O, Goehringer F, Venner C, Selton-Suty C; l'Endocarditis Team du CHU de Nancy. [Treatment of infectious endocarditis]. Presse Med. 2019 May;48(5):539-548. doi: 10.1016/j.lpm.2019.04.015. Epub 2019 May 18. French.

  PMID: 31109766 BACKGROUND

• N'Guyen Y, Duval X, Revest M, Saada M, Erpelding ML, Selton-Suty C, Bouchiat C, Delahaye F, Chirouze C, Alla F, Strady C, Hoen B; AEPEI study group. Time interval between infective endocarditis first symptoms and diagnosis: relationship to infective endocarditis characteristics, microorganisms and prognosis. Ann Med. 2017 Mar;49(2):117-125. doi: 10.1080/07853890.2016.1235282. Epub 2016 Nov 3.

  PMID: 27607562 BACKGROUND

• Lefevre B, Hoen B, Goehringer F, Sime WN, Aissa N, Alauzet C, Jeanmaire E, Henard S, Filippetti L, Selton-Suty C, Agrinier N; for AEPEI study group (Association pour l'Etude et la Prevention de l'Endocardite Infectieuse). Antistaphylococcal penicillins vs. cefazolin in the treatment of methicillin-susceptible Staphylococcus aureus infective endocarditis: a quasi-experimental monocentre study. Eur J Clin Microbiol Infect Dis. 2021 Dec;40(12):2605-2616. doi: 10.1007/s10096-021-04313-3. Epub 2021 Aug 12.

  PMID: 34383175 BACKGROUND

• Collonnaz M, Erpelding ML, Alla F, Goehringer F, Delahaye F, Iung B, Le Moing V, Hoen B, Selton-Suty C, Agrinier N; AEPEI Study Group. Impact of referral bias on prognostic studies outcomes: insights from a population-based cohort study on infective endocarditis. Ann Epidemiol. 2021 Feb;54:29-37. doi: 10.1016/j.annepidem.2020.09.008. Epub 2020 Sep 18.

  PMID: 32950657 BACKGROUND

• Collonnaz M, Erpelding ML, Alla F, Goehringer F, Delahaye F, Iung B, Le Moing V, Hoen B, Selton-Suty C, Agrinier N; AEPEI study group. Data on prognostic factors associated with 3-month and 1-year mortality from infective endocarditis. Data Brief. 2020 Nov 1;33:106478. doi: 10.1016/j.dib.2020.106478. eCollection 2020 Dec.

  PMID: 33225027 BACKGROUND

• De Ciancio G, Erpelding ML, Filippetti L, Goehringer F, Blangy H, Huttin O, Agrinier N, Juilliere Y, Sadoul N, Selton-Suty C. Adherence to diagnostic and therapeutic practice guidelines for suspected cardiac implantable electronic device infections. Arch Cardiovasc Dis. 2021 Oct;114(10):634-646. doi: 10.1016/j.acvd.2021.06.010. Epub 2021 Nov 3.

  PMID: 34742672 BACKGROUND

• Selton-Suty C, Delahaye F, Tattevin P, Federspiel C, Le Moing V, Chirouze C, Nazeyrollas P, Vernet-Garnier V, Bernard Y, Chocron S, Obadia JF, Alla F, Hoen B, Duval X; AEPEI (Association pour l'Etude et la Prevention de l'Endocardite Infectieuse). Symptomatic and Asymptomatic Neurological Complications of Infective Endocarditis: Impact on Surgical Management and Prognosis. PLoS One. 2016 Jul 11;11(7):e0158522. doi: 10.1371/journal.pone.0158522. eCollection 2016.

  PMID: 27400273 BACKGROUND

• Radjabaly Mandjee A, Filippetti L, Goehringer F, Duval X, Botelho-Nevers E, Tribouilloy C, Huguet R, Chirouze C, Erpelding ML, Hoen B, Selton-Suty C, Agrinier N, Lefevre B; investigators of the French AEPEI Observatory on Infective Endocarditis (Association pour l'Etude et la Prevention de l'Endocardite Infectieuse). Characteristics of patients with infective endocarditis and no underlying cardiac conditions. Infect Dis (Lond). 2022 Sep;54(9):656-665. doi: 10.1080/23744235.2022.2078404. Epub 2022 May 23.

  PMID: 35604065 BACKGROUND

• Beraud G, Tubiana S, Erpelding ML, Le Moing V, Chirouze C, Gorenne I, Manchon P, Tattevin P, Vernet V, Varon E, Hoen B, Duval X; AEPEI study group; COMBAT study group. Combined Bacterial Meningitis and Infective Endocarditis: When Should We Search for the Other When Either One is Diagnosed? Infect Dis Ther. 2022 Aug;11(4):1521-1540. doi: 10.1007/s40121-022-00651-7. Epub 2022 May 26.

  PMID: 35618954 BACKGROUND

• Lefevre B, Legoff A, Boutrou M, Goehringer F, Ngueyon-Sime W, Chirouze C, Revest M, Vernet Garnier V, Duval X, Delahaye F, Le Moing V, Selton-Suty C, Filippetti L, Hoen B, Agrinier N. Staphylococcus aureus endocarditis: Identifying prognostic factors using a method derived from morbidity and mortality conferences. Front Med (Lausanne). 2022 Dec 6;9:1053278. doi: 10.3389/fmed.2022.1053278. eCollection 2022.

  PMID: 36561723 BACKGROUND

• Fowler VG, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis AL, Dahl A, DiBernardo L, Durante-Mangoni E, Duval X, Fortes CQ, Fosbol E, Hannan MM, Hasse B, Hoen B, Karchmer AW, Mestres CA, Petti CA, Pizzi MN, Preston SD, Roque A, Vandenesch F, van der Meer JTM, van der Vaart TW, Miro JM. The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. Clin Infect Dis. 2023 Aug 22;77(4):518-526. doi: 10.1093/cid/ciad271.

  PMID: 37138445 BACKGROUND

• El Hatimi S, Erpelding ML, Selton-Suty C, Botros JB, Goehringer F, Berthelot E, Elfarra M, Deconinck L, Para M, Provenchere S, Hoen B, Agrinier N, Duval X, Iung B. Predictive performance of surgical mortality risk scores in infective endocarditis. Eur J Cardiothorac Surg. 2024 Jan 2;65(1):ezad433. doi: 10.1093/ejcts/ezad433.

  PMID: 38175782 BACKGROUND

• Bucy L, Erpelding ML, Boursier C, Lefevre B, Alauzet C, Liu Y, Chevalier E, Huttin O, Agrinier N, Selton-Suty C, Goehringer F; AEPEI study group (Association pour l'Etude et la Prevention de l'Endocardite Infectieuse). Real world experience of therapeutic monitoring of medically treated prosthetic valve infective endocarditis by 18F-FDG-PET/CT. J Nucl Cardiol. 2023 Oct;30(5):2096-2103. doi: 10.1007/s12350-023-03339-8. Epub 2023 Jul 31.

  PMID: 37524996 BACKGROUND

• Goehringer F, Lalloue B, Selton-Suty C, Alla F, Botelho-Nevers E, Chirouze C, Curlier E, El Hatimi S, Gagneux-Brunon A, le Moing V, Lim P, Piroth L, Strady C, Tribouilloy C, Virion JM, Agrinier N, Duval X, Hoen B; Association pour l'Etude et la Prevention de l'Endocardite Infectieuse-ObservatoireEI Study Group. Compared Performance of the 2023 Duke-International Society for Cardiovascular Infectious Diseases, 2000 Modified Duke, and 2015 European Society of Cardiology Criteria for the Diagnosis of Infective Endocarditis in a French Multicenter Prospective Cohort. Clin Infect Dis. 2024 Apr 10;78(4):937-948. doi: 10.1093/cid/ciae035.

  PMID: 38330171 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum, plasma

MeSH Terms

Conditions

Endocarditis

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Christine SELTON-SUTY, MD

  CHRU Nancy

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nadine JUGE, PhD

CONTACT

n.juge@chru-nancy.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: August 28, 2017
• First Posted: September 6, 2017
• Study Start: January 1, 1991
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2027
• Last Updated: September 23, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)