NCT03267199

Brief Summary

  • The relationship between admission MPV, PDW, platelet function test and ST-segment resolution in STEMI patients treated with either thrombolytic therapy or primary percutaneous coronary intervention
  • The relationship between admission MPV, PDW, platelet function test and high thrombus burden \& post-PCI Thrombolysis In Myocardial Infarction (TIMI) flow of infarct related artery in STEMI patients treated with primary percutaneous coronary intervention

Trial Health

15
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Timeline
Completed

Started Dec 2020

Shorter than P25 for all trials

Status
withdrawn

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 25, 2017

Completed
5 days until next milestone

First Posted

Study publicly available on registry

August 30, 2017

Completed
3.3 years until next milestone

Study Start

First participant enrolled

December 1, 2020

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2020

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2021

Completed
Last Updated

February 3, 2023

Status Verified

February 1, 2023

Enrollment Period

Same day

First QC Date

August 25, 2017

Last Update Submit

February 1, 2023

Conditions

STEMI - ST Elevation Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

  • Correlation between admission MPV ,PDW ,platelet function test and change in ST-segment elevation in STEMI patients assessed by CBC ,platelet function test & ECG

    Correlation between admission MPV ,PDW ,platelet function test and change in ST-segment elevation in STEMI patients treated with either thrombolytic therapy or primary percutaneous coronary intervention assessed by CBC,platelet function test \& ECG

    Baseline and 90 min after either the beginning treatment with thrombolytic therapy or primary PCI

Secondary Outcomes (2)

  • Correlation between MPV,PDW,platelet function test and TIMI flow of infarct related artery in STEMI patients treated with primary PCI

    Baseline

  • Correlation between MPV,PDW,platelet function test and high thrombus burden of infarct related artery in STEMI patients treated with primary PCI

    Baseline

Study Arms (2)

patients with high MPV,PDW,PFT

patients with high MPV,PDW,platelet function test

Drug: ThrombolyticProcedure: Primary PCIDiagnostic Test: Complete blood countDiagnostic Test: Platelet function testDiagnostic Test: ECG

patients with normal or low MPV,PDW, PFT

patients with normal or low MPV,PDW,platelet function test

Drug: ThrombolyticProcedure: Primary PCIDiagnostic Test: Complete blood countDiagnostic Test: Platelet function testDiagnostic Test: ECG

Interventions

ThrombolyticDRUG

Thrombolytic therapy

patients with high MPV,PDW,PFTpatients with normal or low MPV,PDW, PFT
Primary PCIPROCEDURE

Primary percutaneous coronary intervention

patients with high MPV,PDW,PFTpatients with normal or low MPV,PDW, PFT
Complete blood countDIAGNOSTIC_TEST

Blood sample for complete blood count

patients with high MPV,PDW,PFTpatients with normal or low MPV,PDW, PFT
Platelet function testDIAGNOSTIC_TEST

Blood sample for platelet function test

patients with high MPV,PDW,PFTpatients with normal or low MPV,PDW, PFT
ECGDIAGNOSTIC_TEST

Electrocardiogram

patients with high MPV,PDW,PFTpatients with normal or low MPV,PDW, PFT

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patients with STEMI presented who will be treated with either thrombolytic therapy or primary PCI in assiut university cath lab will be included in the study

You may qualify if:

  • patients with STEMI presented who will be treated with either thrombolytic therapy or primary PCI in assiut university cath lab will be included in the study

You may not qualify if:

  • Patient with complete LBBB on admission ECG
  • Active infection
  • Documented systemic inflammatory disease
  • Malignancy
  • End-stage liver
  • Renal failure
  • Patient receiving oral anticoagulation medicine
  • Bleeding diathesis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

ST Elevation Myocardial Infarction

Interventions

Fibrinolytic AgentsBlood Cell CountPlatelet Function TestsElectrocardiography

Condition Hierarchy (Ancestors)

Myocardial InfarctionMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Intervention Hierarchy (Ancestors)

Fibrin Modulating AgentsMolecular Mechanisms of Pharmacological ActionPharmacologic ActionsChemical Actions and UsesCardiovascular AgentsTherapeutic UsesHematologic AgentsCell CountCytological TechniquesClinical Laboratory TechniquesDiagnostic Techniques and ProceduresDiagnosisHematologic TestsInvestigative TechniquesCell Physiological PhenomenaBlood Physiological PhenomenaCirculatory and Respiratory Physiological PhenomenaHeart Function TestsDiagnostic Techniques, CardiovascularElectrodiagnosis
0

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
resident physician

Study Record Dates

First Submitted

August 25, 2017

First Posted

August 30, 2017

Study Start

December 1, 2020

Primary Completion

December 1, 2020

Study Completion

August 1, 2021

Last Updated

February 3, 2023

Record last verified: 2023-02