NCT03259321

Brief Summary

The role of fishery diet and polyunsaturated fatty acids (PUFA) in the development of type 2 diabetes (T2D) is heavily debated but evidence from large populations in China is scant. The investigators aim to use data from the China Health and Nutrition Survey (CHNS) to assess the long-term association between fish, PUFA intake and T2D risk.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
15,100

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 1989

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 1989

Completed
23 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2011

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2012

Completed
4.6 years until next milestone

First Submitted

Initial submission to the registry

August 21, 2017

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 23, 2017

Completed
Last Updated

March 15, 2024

Status Verified

March 1, 2024

Enrollment Period

23 years

First QC Date

August 21, 2017

Last Update Submit

March 12, 2024

Conditions

Type2 Diabetes

Keywords

FishPolyunsaturated fatty acidsCHNS

Outcome Measures

Primary Outcomes (1)

  • Type 2 diabetes

    Incidence of type 2 diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5%

    From entry into the study (baseline: 1997-2009) until 2011

Secondary Outcomes (1)

  • Fish and polyunsaturated fatty acids intake

    From entry into the study (baseline: 1997-2009) until 2011

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

CHNS is an ongoing, large-scale, household-based cohort starting in 1989. The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population.

You may qualify if:

  • Adults aged ≥20 with complete data on diet and follow-up time

You may not qualify if:

  • Missing information for Type 2 diabetes
  • Type 2 diabetes
  • Cardiovascular disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (3)

  • Zhuang P, Mao L, Wu F, Wang J, Jiao J, Zhang Y. Cooking Oil Consumption Is Positively Associated with Risk of Type 2 Diabetes in a Chinese Nationwide Cohort Study. J Nutr. 2020 Jul 1;150(7):1799-1807. doi: 10.1093/jn/nxaa103.

    PMID: 32364230DERIVED

  • Wu F, Mao L, Zhuang P, Chen X, Jiao J, Zhang Y. Plant-sourced cooking oil consumption is associated with lower total mortality in a longitudinal nationwide cohort study. Clin Nutr. 2020 Dec;39(12):3703-3710. doi: 10.1016/j.clnu.2020.03.031. Epub 2020 Apr 2.

    PMID: 32359931DERIVED

  • Zhuang P, Shou Q, Wang W, He L, Wang J, Chen J, Zhang Y, Jiao J. Essential Fatty Acids Linoleic Acid and alpha-Linolenic Acid Sex-Dependently Regulate Glucose Homeostasis in Obesity. Mol Nutr Food Res. 2018 Sep;62(17):e1800448. doi: 10.1002/mnfr.201800448. Epub 2018 Aug 12.

    PMID: 29935107DERIVED

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

August 21, 2017

First Posted

August 23, 2017

Study Start

January 1, 1989

Primary Completion

December 31, 2011

Study Completion

December 31, 2012

Last Updated

March 15, 2024

Record last verified: 2024-03