Dietary Intake in Adults From the GA2LEN Folow-up Survey

NCT03251157 | Completed

• 1 other identifier: GA2LEN Nutrition Survey
• Study Type: observational
• Target: 3,500
• Locations: 1 country
• Sites: 1

Brief Summary

The Nutrition Study of the GA2LEN Follow-Survey was designed to investigate the association between usual dietary intake and allergic and respiratory outcomes in adults across Europe. Within this framework, a food frequency questionnaire (FFQ) was designed to ascertain usual dietary intake of 250 food items, which was translated into the languages of the participant centres. Information on daily intake of foods, nutrients, and flavonoids was derived.

Conditions

Asthma; Lung Function Decreased; Food Allergy; Allergic Sensitisation; Allergic Rhinitis; COPD; Atopy

Keywords

Asthma; Adults; Europe; Lung function; Allergy; Atopy; IgE; Sensitisation; Diet; Dietary patterns; Dietary antioxidants; Flavonoids; Fruits and vegetables; Food frequency questionnaire (FFQ); Fatty acids

Outcome Measures

Primary Outcomes (5)

• Asthma score

  Five questions on symptoms in the last 12 months (breathless when wheezing, woken with tightness in chest, shortness of breath while at rest, shortness of breath after exercise, woken by shortness of breath) were used to construct an asthma symptom score on a five-point scale

  Last 12 months

• Chronic rhinosinusitis (CRS)

  defined following the EP3OS criteria, that is, the presence of at least two of the following symptoms for at least 12 weeks in the past year: (i) nasal blockage, (ii) nasal discharge, (iii) facial pain or pressure or (iv) reduction in sense of smell with at least one of the symptoms being nasal blockage or nasal discharge

  Last 12 weeks

• Lung function

  Spirometric lung function (Forced Expiratory Volume in one second (FEV1), and Forced Vital Capacity (FVC)) were measured pre- and post- administration of bronchodilator (salbutamol 200 mg). Spirometric restriction was defined by an FVC below the limit of normal, chronic obstruction by an FEV1/FVC below the limit of normal. All spirometries were checked centrally for quality. Only spirometry that met the ERS/ATS criteria was accepted

  Day

• Atopy

  Skin prick tests (SPTs) to grass pollen, grass mix, Dermatophagoides pteronyssinus, Dermatophagoides farinae, cockroach (Blatella), olive, Alternaria, dog, Artemisia, birch, cat and Parietaria were conducted. A SPT was regarded as positive where the allergen weal was \>1 mm more than the diluent control. Atopy was defined as any positive response to any of the allergens tested

  1 day

• Allergic rhinitis

  Defined based on a positive answer to the question 'Do you have any nasal allergies or hay fever'?

  Last month

Other Outcomes (2)

• Asthma

  Last 12 months

• IgE sensitisation

  1 day

Interventions

Dietary intake of various nutrients, foods and biocompounds OTHER

Participants answered a self-administered FFQ, in which they reported the usual frequency of intake of a list of 250 food items

Eligibility Criteria

• Age: 15 Years - 75 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The GA2LEN follow-up study was a multi-center case-control study with participants selected from the respondents to an initial cross-sectional survey of a general population of adults aged 15-74 years living in 17 European cities and completed between June 2007 and May 2009. A random sample of eligible participants who indicated a willingness to be re-contacted was selected based on their responses to the initial postal survey. The cases were participants who either had asthma, sinusitis or both and the controls (who lived in the same areas) were those who reported having neither. Each center recruited up to 120 cases each of patients with asthma only, CRS only, controls and 40 patients with both asthma and CRS based on the responses to the initial cross-sectional survey.

You may qualify if:

• Participants aged 15-75 years old, who had responded to the GA2LEN Baseline survey and who met the definition of cases or controls (as described below)

You may not qualify if:

• Participants who did not answer the baseline survey

Sponsors & Collaborators

• Johns Hopkins Bloomberg School of Public Health: lead
• Imperial College London: collaborator
• Helsinki University Central Hospital: collaborator
• Medical University of Lodz: collaborator
• Karolinska Institutet: collaborator
• University Ghent: collaborator
• University of Wuerzburg: collaborator
• Medical University of Silesia: collaborator
• University of Coimbra: collaborator
• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA): collaborator
• University of Southern Denmark: collaborator
• Uppsala University: collaborator
• Umeå University: collaborator
• Charite University, Berlin, Germany: collaborator
• University of Southampton: collaborator
• Göteborg University: collaborator
• Jagiellonian University: collaborator
• Odense University Hospital: collaborator

Study Sites (1)

Johns Hopkins Bloomberg School of Public Health

Baltimore, Maryland, 21205, United States

Location

Related Publications (3)

• Bousquet J, Burney PG, Zuberbier T, Cauwenberge PV, Akdis CA, Bindslev-Jensen C, Bonini S, Fokkens WJ, Kauffmann F, Kowalski ML, Lodrup-Carlsen K, Mullol J, Nizankowska-Mogilnicka E, Papadopoulos N, Toskala E, Wickman M, Anto J, Auvergne N, Bachert C, Bousquet PJ, Brunekreef B, Canonica GW, Carlsen KH, Gjomarkaj M, Haahtela T, Howarth P, Lenzen G, Lotvall J, Radon K, Ring J, Salapatas M, Schunemann HJ, Szczecklik A, Todo-Bom A, Valovirta E, von Mutius E, Zock JP. GA2LEN (Global Allergy and Asthma European Network) addresses the allergy and asthma 'epidemic'. Allergy. 2009 Jul;64(7):969-77. doi: 10.1111/j.1398-9995.2009.02059.x. Epub 2009 Apr 7.

  PMID: 19392994 BACKGROUND

• Garcia-Larsen V, Arthur R, Potts JF, Howarth PH, Ahlstrom M, Haahtela T, Loureiro C, Bom AT, Brozek G, Makowska J, Kowalski ML, Thilsing T, Keil T, Matricardi PM, Toren K, van Zele T, Bachert C, Rymarczyk B, Janson C, Forsberg B, Nizankowska-Mogilnicka E, Burney PGJ. Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey. Clin Transl Allergy. 2017 Jan 27;7:3. doi: 10.1186/s13601-016-0140-9. eCollection 2017.

  PMID: 28149501 BACKGROUND

• Garcia-Larsen V, Luczynska M, Kowalski ML, Voutilainen H, Ahlstrom M, Haahtela T, Toskala E, Bockelbrink A, Lee HH, Vassilopoulou E, Papadopoulos NG, Ramalho R, Moreira A, Delgado L, Castel-Branco MG, Calder PC, Childs CE, Bakolis I, Hooper R, Burney PG; GA2LEN-WP 1.2 'Epidemiological and Clinical Studies'. Use of a common food frequency questionnaire (FFQ) to assess dietary patterns and their relation to allergy and asthma in Europe: pilot study of the GA2LEN FFQ. Eur J Clin Nutr. 2011 Jun;65(6):750-6. doi: 10.1038/ejcn.2011.15. Epub 2011 Mar 23.

  PMID: 21427744 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Participants had serum taken which was stored frozen and subsequently analysed in a central laboratory to estimate concentration of several biomarkers including hormones (e.g. leptin), markers of inflammation (cytokines CRP, Interleukin 6 (IL-6), Interleukin 8 (IL-8), Tumour Necrosis Factor alpha (TNF-α) Transforming Growth Factor beta (TGF-β) and Myeloperoxidase (MPO)), and serum levels of total and allergen-specific IgEs.

MeSH Terms

Conditions

Asthma; Respiratory Insufficiency; Food Hypersensitivity; Rhinitis, Allergic; Pulmonary Disease, Chronic Obstructive; Hypersensitivity

Interventions

Food

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Immune System Diseases; Respiration Disorders; Rhinitis; Nose Diseases; Otorhinolaryngologic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Peter GJ Burney, MD PhD

  Imperial College London

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor in Human Nutrition

Study Record Dates

• First Submitted: August 12, 2017
• First Posted: August 16, 2017
• Study Start: January 1, 2007
• Primary Completion: December 31, 2010
• Study Completion: December 31, 2010
• Last Updated: August 16, 2017

Record last verified: 2017-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)