Study of Sensorimotor Compatibility Effects in Bipolar Affective Disorder.

NCT03249857 | Completed

• 2 other identifiers: 17080562017-A00917-46
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Based in an embodied approach of cognition, several studies have highlighted a direct link between perception of an object or an emotion and the associated motor responses. This study investigated in patients suffering from bipolar affective disorders whether the perception of emotional words involves an automatic sensorimotor simulation of approach and avoidance behaviors, and whether the perception of an object involves an automatic sensorimotor simulation of object prehension (affordance). We hypothesize that, in this pathology, low level (sensorimotor) cognitive processes are preserved whereas high-level (attentional) are altered. 20 patients suffering from bipolar affective disorders and 20 healthy controls will be recruited. The main objective is the emergence of sensorimotor compatibility effects in approach-avoidance task with emotional stimuli (gain between compatible vs incompatible conditions).

Conditions

Bipolar Affective Disorder

Keywords

Bipolar affective disorders; Cognition; Emotion; Embodiment; Sensorimotor; Simulation

Outcome Measures

Primary Outcomes (1)

• response time for avoidance and affordance task

  Comparison of response time for avoidance and affordance task between patients and healthy volunteers.

  Months 24

Secondary Outcomes (3)

• response time for affordance task

  Months 24

• correlations with age at onset of the disease, the number of thymic decompensations and the existence of psychotic symptoms

  Months 24

• response time and cognitive tests

  Months 24

Study Arms (2)

patients

EXPERIMENTAL

Patients suffering bipolar affective disorders and who will perform cognitive tasks + IQ + MINI + experimental task

Behavioral: cognitive tasks + IQ + MINI

control group

ACTIVE COMPARATOR

Healthy volunteers (Control group) who will perform cognitive tasks + experimental task

Behavioral: cognitive tasks

Interventions

cognitive tasks + IQ + MINI BEHAVIORAL

Patients will perform different tasks: * cognitive tasks : reaction time (Alert TEA, Zimmermann and Fimm, 2005) + Edinburgh laterality questionnaire (Oldfield,1971) + hamilton and young's scale (Tohen et al., 2009) + Montreal Cognitive Assessment (MoCA) (Nasreddine et al., 2005) + experimental task (approach/ avoidance and affordance task). * Intelligence Quotient (IQ) test (PM38, Raven, 1960) * Mini International Neuropsychiatric Interview (MINI, Van Vliet et al., 2006)

patients

cognitive tasks BEHAVIORAL

Healthy volunteers will perform only the cognitive tasks = reaction time alert TEA, Zimmermann and Fimm, 2005 + Edinburgh laterality questionnaire (Oldfield, 1971) + experimental task (approach/ avoidance and affordance task).

control group

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• For patients:
• Affiliated or entitled to a social security
• Aged between 18 and 55
• Patients of both sexes suffering from bipolar disorders (DSM V criteria) whatever the subtype
• Stabilized from a point of view clinical and therapeutic
• Euthymic (score \<7 at the Hamilton scale, and score \<8 at Young's scale)
• Must have given their informed consent before their participation in the study
• Be right-handed (score\> 14 on the laterality scale)
• For control group:
• Affiliated or entitled to a social security
• Must have given their informed consent before their participation in the study
• Be right-handed (score\> 14 on the lateral scale)
• Aged 18 to 55 matched by age (± 5 years), sex, and on the study level of patients (years of schooling after primary school ± 2 years)

You may not qualify if:

• For patients:
• Thymic acute decompensation
• Hamilton scale \> 8, Young's scale \> 9
• Montreal Cognitive Assessment (MOCA) \<26
• History neurological pathology with cerebral impairment or serious somatic disease
• Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal) within 6 months.
• IQ \< 70
• History of head trauma
• For control group:
• History of head trauma
• Neurological pathology with cerebral impairment or serious somatic disease
• Psychotropic treatment
• Disorders related to the use of a psychoactive substance, as defined by the DSM-V (abuse, dependence or withdrawal)
• IQ \< 70

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

Chu Saint-Etienne

Saint-Etienne, 42055, France

Location

MeSH Terms

Conditions

Bipolar Disorder

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders

Study Officials

• Catherine MASSOUBRE, MD PhD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 10, 2017
• First Posted: August 15, 2017
• Study Start: October 26, 2017
• Primary Completion: August 21, 2018
• Study Completion: August 21, 2018
• Last Updated: January 9, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)